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B4GALT3 beta-1,4-galactosyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 8703, updated on 13-Mar-2020

Summary

Official Symbol
B4GALT3provided by HGNC
Official Full Name
beta-1,4-galactosyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:926
See related
Ensembl:ENSG00000158850 MIM:604014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
beta4Gal-T3
Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in placenta (RPKM 11.2), testis (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See B4GALT3 in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161171310..161185007, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161141100..161147758, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene linc-UFC1 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene protoporphyrinogen oxidase Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene Fc fragment of IgE receptor Ig

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 (B4GALT3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetyllactosamine synthase activity IEA
Inferred from Electronic Annotation
more info
 
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
galactosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
galactosylceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,4-galactosyltransferase 3
Names
N-acetyllactosamine synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
b4Gal-T3
beta-1,4-GalTase 3
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 3
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
epididymis secretory sperm binding protein
nal synthase
NP_001186802.1
NP_001186803.1
NP_003770.1
XP_005245623.1
XP_011508395.1
XP_016858203.1
XP_024306308.1
XP_024306309.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011480.1 RefSeqGene

    Range
    5018..11215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199873.1NP_001186802.1  beta-1,4-galactosyltransferase 3

    See identical proteins and their annotated locations for NP_001186802.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK291455, AL590714, BC006099, DC339671
    Consensus CDS
    CCDS1222.1
    UniProtKB/Swiss-Prot
    O60512
    UniProtKB/TrEMBL
    A8K5Z0
    Related
    ENSP00000480428.1, ENST00000622395.4
    Conserved Domains (1) summary
    cd00899
    Location:122341
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. NM_001199874.1NP_001186803.1  beta-1,4-galactosyltransferase 3

    See identical proteins and their annotated locations for NP_001186803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AK291455, BC006099, BC009985, DC339671
    Consensus CDS
    CCDS1222.1
    UniProtKB/Swiss-Prot
    O60512
    UniProtKB/TrEMBL
    A8K5Z0
    Related
    ENSP00000356977.1, ENST00000367998.5
    Conserved Domains (1) summary
    cd00899
    Location:122341
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  3. NM_003779.4NP_003770.1  beta-1,4-galactosyltransferase 3

    See identical proteins and their annotated locations for NP_003770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AK291455, BC006099, DC339671
    Consensus CDS
    CCDS1222.1
    UniProtKB/Swiss-Prot
    O60512
    UniProtKB/TrEMBL
    A8K5Z0
    Related
    ENSP00000320965.5, ENST00000319769.10
    Conserved Domains (1) summary
    cd00899
    Location:122341
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161171310..161185007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002714.2XP_016858203.1  beta-1,4-galactosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    cd00899
    Location:122303
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. XM_011510093.2XP_011508395.1  beta-1,4-galactosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    cd00899
    Location:122303
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  3. XM_024450540.1XP_024306308.1  beta-1,4-galactosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    cd00899
    Location:122341
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  4. XM_024450541.1XP_024306309.1  beta-1,4-galactosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    cd00899
    Location:122341
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  5. XM_005245566.2XP_005245623.1  beta-1,4-galactosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_005245623.1

    UniProtKB/Swiss-Prot
    O60512
    Conserved Domains (1) summary
    cd00899
    Location:122341
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RNA

  1. XR_002957952.1 RNA Sequence

  2. XR_002957951.1 RNA Sequence

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