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S1PR4 sphingosine-1-phosphate receptor 4 [ Homo sapiens (human) ]

Gene ID: 8698, updated on 24-Nov-2020

Summary

Official Symbol
S1PR4provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 4provided by HGNC
Primary source
HGNC:HGNC:3170
See related
Ensembl:ENSG00000125910 MIM:603751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG6; LPC1; S1P4; SLP4
Summary
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See S1PR4 in Genome Data Viewer
Location:
19p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3178769..3180332)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3178250..3180335)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene GNA15 divergent transcript Neighboring gene G protein subunit alpha 15 Neighboring gene Sharpr-MPRA regulatory region 13242 Neighboring gene nicalin Neighboring gene CUGBP Elav-like family member 5 Neighboring gene uncharacterized LOC105372244

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 4
Names
S1P receptor 4
S1P receptor Edg-6
endothelial differentiation G-protein coupled receptor 6
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
sphingosine 1-phosphate receptor Edg-6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003775.4NP_003766.1  sphingosine 1-phosphate receptor 4 precursor

    See identical proteins and their annotated locations for NP_003766.1

    Status: REVIEWED

    Source sequence(s)
    BC014970
    Consensus CDS
    CCDS12105.1
    UniProtKB/Swiss-Prot
    O95977
    Related
    ENSP00000246115.3, ENST00000246115.5
    Conserved Domains (2) summary
    cd14964
    Location:4973
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:47318
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3178769..3180332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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