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CDC23 cell division cycle 23 [ Homo sapiens (human) ]

Gene ID: 8697, updated on 24-Nov-2020

Summary

Official Symbol
CDC23provided by HGNC
Official Full Name
cell division cycle 23provided by HGNC
Primary source
HGNC:HGNC:1724
See related
Ensembl:ENSG00000094880 MIM:603462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC8; CUT23; ANAPC8
Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See CDC23 in Genome Data Viewer
Location:
5q31.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (138187650..138213323, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137523337..137549032, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 888, pseudogene Neighboring gene NME/NM23 family member 5 Neighboring gene bromodomain containing 8 Neighboring gene Sharpr-MPRA regulatory region 11877 Neighboring gene kinesin family member 20A Neighboring gene Sharpr-MPRA regulatory region 7870 Neighboring gene GDNF family receptor alpha 3 Neighboring gene RPS27A pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic metaphase plate congression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exit from mitosis TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of mitotic metaphase/anaphase transition IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cell division cycle protein 23 homolog
Names
anaphase-promoting complex subunit 8
cell division cycle 23 homolog
cyclosome subunit 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004661.4NP_004652.2  cell division cycle protein 23 homolog

    See identical proteins and their annotated locations for NP_004652.2

    Status: REVIEWED

    Source sequence(s)
    AC106752, BC017713
    Consensus CDS
    CCDS4200.2
    UniProtKB/Swiss-Prot
    Q9UJX2
    Related
    ENSP00000378350.2, ENST00000394886.7
    Conserved Domains (3) summary
    COG2956
    Location:214491
    YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]
    sd00006
    Location:367393
    TPR; TPR repeat [structural motif]
    pfam04049
    Location:45148
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    138187650..138213323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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