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KRT36 keratin 36 [ Homo sapiens (human) ]

Gene ID: 8689, updated on 8-Jul-2021

Summary

Official Symbol
KRT36provided by HGNC
Official Full Name
keratin 36provided by HGNC
Primary source
HGNC:HGNC:6454
See related
Ensembl:ENSG00000126337 MIM:604540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA6; hHa6; KRTHA6
Summary
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT36 in Genome Data Viewer
Location:
17q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41486136..41489910, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39642388..39646162, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 32 Neighboring gene RNA, U2 small nuclear 32, pseudogene Neighboring gene keratin 35 Neighboring gene keratin 13 Neighboring gene keratin 15 Neighboring gene microRNA 6510

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of skin epidermis NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha6
Names
K36
hair keratin, type I Ha6
keratin 36, type I
keratin, hair, acidic, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012293.1 RefSeqGene

    Range
    5001..8729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003771.5NP_003762.1  keratin, type I cuticular Ha6

    See identical proteins and their annotated locations for NP_003762.1

    Status: VALIDATED

    Source sequence(s)
    AC019349
    Consensus CDS
    CCDS11395.1
    UniProtKB/Swiss-Prot
    O76013
    Related
    ENSP00000329165.6, ENST00000328119.11
    Conserved Domains (1) summary
    pfam00038
    Location:92403
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41486136..41489910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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