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KRT38 keratin 38 [ Homo sapiens (human) ]

Gene ID: 8687, updated on 8-Jul-2021

Summary

Official Symbol
KRT38provided by HGNC
Official Full Name
keratin 38provided by HGNC
Primary source
HGNC:HGNC:6456
See related
Ensembl:ENSG00000171360 MIM:604542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA8; hHa8; KRTHA8
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT38 in Genome Data Viewer
Location:
17q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41436154..41440983, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39592406..39597235, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505782 Neighboring gene keratin 41, pseudogene Neighboring gene keratin 37 Neighboring gene keratin 43 pseudogene Neighboring gene keratin 32 Neighboring gene RNA, U2 small nuclear 32, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha8
Names
K38
hair keratin, type I Ha8
keratin 38, type I
keratin, hair, acidic, 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012295.1 RefSeqGene

    Range
    5001..9976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006771.4NP_006762.3  keratin, type I cuticular Ha8

    See identical proteins and their annotated locations for NP_006762.3

    Status: VALIDATED

    Source sequence(s)
    AC019349, BC131715
    Consensus CDS
    CCDS11392.1
    UniProtKB/Swiss-Prot
    O76015
    Related
    ENSP00000246646.3, ENST00000246646.4
    Conserved Domains (2) summary
    pfam00038
    Location:104414
    Filament; Intermediate filament protein
    pfam08286
    Location:204273
    Spc24; Spc24 subunit of Ndc80

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41436154..41440983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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