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MARCO macrophage receptor with collagenous structure [ Homo sapiens (human) ]

Gene ID: 8685, updated on 12-Oct-2019

Summary

Official Symbol
MARCOprovided by HGNC
Official Full Name
macrophage receptor with collagenous structureprovided by HGNC
Primary source
HGNC:HGNC:6895
See related
Ensembl:ENSG00000019169 MIM:604870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR-A6; SCARA2
Summary
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues See more
Orthologs

Genomic context

See MARCO in Genome Data Viewer
Location:
2q14.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (118942169..118994664)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119699745..119752236)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927709 Neighboring gene engrailed homeobox 1 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene complement C1q like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr potentiates the stimulation of macrophage receptor with collagenous structure by glucocorticoids via the glucocorticoid receptor pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
signaling pattern recognition receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
pattern recognition receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen type XI trimer IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
macrophage receptor MARCO
Names
scavenger receptor class A, member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006770.3NP_006761.1  macrophage receptor MARCO

    See identical proteins and their annotated locations for NP_006761.1

    Status: REVIEWED

    Source sequence(s)
    AF035819, BC016004, CB529479
    Consensus CDS
    CCDS2124.1
    UniProtKB/Swiss-Prot
    Q9UEW3
    UniProtKB/TrEMBL
    Q4ZG40
    Related
    ENSP00000318916.4, ENST00000327097.4
    Conserved Domains (2) summary
    pfam01391
    Location:286344
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:424519
    SR; Scavenger receptor Cys-rich

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    118942169..118994664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512082.2XP_011510384.1  macrophage receptor MARCO isoform X1

    See identical proteins and their annotated locations for XP_011510384.1

    UniProtKB/Swiss-Prot
    Q9UEW3
    UniProtKB/TrEMBL
    Q4ZG40
    Conserved Domains (2) summary
    pfam01391
    Location:286344
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:424519
    SR; Scavenger receptor Cys-rich
  2. XM_017005171.2XP_016860660.1  macrophage receptor MARCO isoform X3

  3. XM_011512083.3XP_011510385.1  macrophage receptor MARCO isoform X2

    Conserved Domains (3) summary
    pfam01391
    Location:165223
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:303398
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:308398
    SRCR; Scavenger receptor cysteine-rich domain
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