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STX10 syntaxin 10 [ Homo sapiens (human) ]

Gene ID: 8677, updated on 7-May-2017
Official Symbol
STX10provided by HGNC
Official Full Name
syntaxin 10provided by HGNC
Primary source
HGNC:HGNC:11428
See related
Ensembl:ENSG00000104915 MIM:603765; Vega:OTTHUMG00000180759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYN10; hsyn10
Summary
This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Orthologs
Location:
19p13.13
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (13144058..13150374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13254872..13261188, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372282 Neighboring gene tRNA methyltransferase 1 Neighboring gene nucleus accumbens associated 1 Neighboring gene immediate early response 2 Neighboring gene ribosomal protein L12 pseudogene 42

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT early endosome to Golgi transport IDA
Inferred from Direct Assay
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271609.1NP_001258538.1  syntaxin-10 isoform 2

    See identical proteins and their annotated locations for NP_001258538.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC095459, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS62570.1
    UniProtKB/TrEMBL
    X6R2W0
    Related
    ENSP00000242770.5, OTTHUMP00000265216, ENST00000242770.9, OTTHUMT00000452916
    Conserved Domains (2) summary
    pfam09177
    Location:13103
    Syntaxin-6_N; Syntaxin 6, N-terminal
    cl22856
    Location:160192
    SNARE; SNARE motif
  2. NM_001271610.1NP_001258539.1  syntaxin-10 isoform 3

    See identical proteins and their annotated locations for NP_001258539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY778966, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS62569.1
    UniProtKB/TrEMBL
    Q5U8S2
    Related
    ENSP00000465398.1, OTTHUMP00000265217, ENST00000589083.5, OTTHUMT00000452917
    Conserved Domains (2) summary
    cd15851
    Location:160225
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13103
    Syntaxin-6_N; Syntaxin 6, N-terminal
  3. NM_001271611.1NP_001258540.1  syntaxin-10 isoform 4

    See identical proteins and their annotated locations for NP_001258540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites and lacks an internal exon, resulting in the loss of an in-frame segment in the coding region, compared to variant 1. This results in a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    BC017237, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS62571.1
    UniProtKB/Swiss-Prot
    O60499
    Related
    ENSP00000339350.4, OTTHUMP00000265214, ENST00000343587.9, OTTHUMT00000452914
    Conserved Domains (2) summary
    cd15851
    Location:111176
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:1377
    Syntaxin-6_N; Syntaxin 6, N-terminal
  4. NM_003765.2NP_003756.1  syntaxin-10 isoform 1

    See identical proteins and their annotated locations for NP_003756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF035531, BM830816, BM847745, CD364936
    Consensus CDS
    CCDS32922.1
    UniProtKB/Swiss-Prot
    O60499
    Related
    ENSP00000466298.1, OTTHUMP00000265218, ENST00000587230.5, OTTHUMT00000452918
    Conserved Domains (2) summary
    cd15851
    Location:160225
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13103
    Syntaxin-6_N; Syntaxin 6, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

    Range
    13144058..13150374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528397.2XP_011526699.1  syntaxin-10 isoform X1

    Conserved Domains (1) summary
    pfam09177
    Location:13103
    Syntaxin-6_N; Syntaxin 6, N-terminal

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    13255825..13262142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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