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mgl Megalin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674055, updated on 29-Dec-2023

Summary

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Official Symbol
mglprovided by FlyBase
Official Full Name
Megalinprovided by FlyBase
Primary source
FLYBASE:FBgn0261260
Locus tag
Dmel_CG42611
See related
AllianceGenome:FB:FBgn0261260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.108; CG12139; CG12654; CG15316; CG34339; CG34352; CG42611; CT7830; Dm CG34352; Dmel\CG42611; LDLR; LRP-2; lrp2; megalin; Mgl; SOSIE
Old locus tag
CG12139; CG12654; Dmel_CG12139; Dmel_CG12654; Dmel_CG34339; Dmel_CG34352
Summary
Predicted to enable hormone binding activity. Involved in chitin-based cuticle development; regulation of adult chitin-containing cuticle pigmentation; and regulation of endocytosis. Located in apical plasma membrane. Is expressed in several structures, including early extended germ band embryo; ectoderm; extraembryonic structure; head; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
8D9-8E4; 1-28 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9358496..9500129, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9252529..9394162, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene c12.2 Neighboring gene Zinc finger DHHC-type containing 8 Neighboring gene uncharacterized protein Neighboring gene BCL7-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uncovering the footprint of positive selection on the X chromosome of Drosophila melanogaster. Orengo DJ, et al. Mol Biol Evol, 2010 Jan. PMID 19759233
  2. Revisiting the developmental and cellular role of the pigmentation gene yellow in Drosophila using a tagged allele. Hinaux H, et al. Dev Biol, 2018 Jun 15. PMID 29634916
  3. Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation. Kim JH, et al. Food Chem Toxicol, 2021 May. PMID 33774094, Free PMC Article
  4. V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis. Gleixner EM, et al. Cell Rep, 2014 Jul 10. PMID 24953654
  5. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Logan MA, et al. Nat Neurosci, 2012 Mar 18. PMID 22426252, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
    Title: Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of adult chitin-containing cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
megalin
Names
CG42611-PA
CG42611-PC
CG42611-PD
CG42611-PE
LDL receptor-related protein 2
mgl-PA
mgl-PC
mgl-PD
mgl-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9358496..9500129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298124.1 → NP_001285053.1  megalin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285053.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JTM7
    Conserved Domains (11) summary
    smart00192
    Location:1227 → 1259
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2671 → 2713
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4163 → 4194
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:2867 → 2901
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2593 → 2622
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:1188 → 1223
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:4350 → 4390
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:3269 → 3292
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1522 → 1553
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:447 → 488
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:2579 → 2711
    NHL; NHL repeat unit of beta-propeller proteins

  2. NM_001103454.3 → NP_001096924.2  megalin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096924.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JTM7
    Conserved Domains (11) summary
    smart00192
    Location:1227 → 1259
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2671 → 2713
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4163 → 4194
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:2867 → 2901
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2593 → 2622
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:1188 → 1223
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:4350 → 4390
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:3269 → 3292
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1522 → 1553
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:447 → 488
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:2579 → 2711
    NHL; NHL repeat unit of beta-propeller proteins

  3. NM_132335.3 → NP_572563.3  megalin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572563.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JTM7
    Conserved Domains (11) summary
    smart00192
    Location:1227 → 1259
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2671 → 2713
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4163 → 4194
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:2867 → 2901
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2593 → 2622
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:1188 → 1223
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:4350 → 4390
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:3269 → 3292
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1522 → 1553
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:447 → 488
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:2579 → 2711
    NHL; NHL repeat unit of beta-propeller proteins

  4. NM_001298125.1 → NP_001285054.1  megalin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285054.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JTM7
    Conserved Domains (11) summary
    smart00192
    Location:1227 → 1259
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2671 → 2713
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4163 → 4194
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:2867 → 2901
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2593 → 2622
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:1188 → 1223
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:4350 → 4390
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:3269 → 3292
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1522 → 1553
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:447 → 488
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:2579 → 2711
    NHL; NHL repeat unit of beta-propeller proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JTM7 A8JTM7
Q95SN5 Q95SN5

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