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VAMP8 vesicle associated membrane protein 8 [ Homo sapiens (human) ]

Gene ID: 8673, updated on 9-Jan-2022

Summary

Official Symbol
VAMP8provided by HGNC
Official Full Name
vesicle associated membrane protein 8provided by HGNC
Primary source
HGNC:HGNC:12647
See related
Ensembl:ENSG00000118640 MIM:603177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDB; VAMP-8
Summary
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues See more
Orthologs
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Genomic context

See VAMP8 in Genome Data Viewer
Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85577535..85582031)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85804709..85809154)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene methionine adenosyltransferase 2A Neighboring gene gamma-glutamyl carboxylase Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene vesicle associated membrane protein 5 Neighboring gene ring finger protein 181

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome membrane docking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mucus secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of secretion by cell IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in azurophil granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mucin granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mucin granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicle-associated membrane protein 8
Names
vesicle-associated membrane protein 8 (endobrevin)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022887.1 RefSeqGene

    Range
    5096..9541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003761.5NP_003752.2  vesicle-associated membrane protein 8

    See identical proteins and their annotated locations for NP_003752.2

    Status: REVIEWED

    Source sequence(s)
    BC001634, BM702226, BX092149
    Consensus CDS
    CCDS1979.1
    UniProtKB/Swiss-Prot
    Q9BV40
    Related
    ENSP00000263864.5, ENST00000263864.10
    Conserved Domains (1) summary
    cd15868
    Location:1077
    R-SNARE_VAMP8; SNARE motif of VAMP8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85577535..85582031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005170.1XP_016860659.1  vesicle-associated membrane protein 8 isoform X1

    UniProtKB/TrEMBL
    B8ZZT4
    Related
    ENSP00000387094.1, ENST00000409760.1
    Conserved Domains (1) summary
    cl22856
    Location:1055
    SNARE; SNARE motif
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