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VAMP8 vesicle associated membrane protein 8 [ Homo sapiens (human) ]

Gene ID: 8673, updated on 29-Mar-2020

Summary

Official Symbol
VAMP8provided by HGNC
Official Full Name
vesicle associated membrane protein 8provided by HGNC
Primary source
HGNC:HGNC:12647
See related
Ensembl:ENSG00000118640 MIM:603177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDB; VAMP-8
Summary
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues See more
Orthologs

Genomic context

See VAMP8 in Genome Data Viewer
Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85577535..85582031)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85804614..85809156)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene methionine adenosyltransferase 2A Neighboring gene gamma-glutamyl carboxylase Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene vesicle associated membrane protein 5 Neighboring gene ring finger protein 181

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome membrane docking IDA
Inferred from Direct Assay
more info
PubMed 
NOT eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
mucus secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of secretion by cell IDA
Inferred from Direct Assay
more info
PubMed 
NOT neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
azurophil granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome TAS
Traceable Author Statement
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mucin granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mucin granule IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicle-associated membrane protein 8
Names
vesicle-associated membrane protein 8 (endobrevin)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022887.1 RefSeqGene

    Range
    5096..9541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003761.5NP_003752.2  vesicle-associated membrane protein 8

    See identical proteins and their annotated locations for NP_003752.2

    Status: REVIEWED

    Source sequence(s)
    BC001634, BM702226, BX092149
    Consensus CDS
    CCDS1979.1
    UniProtKB/Swiss-Prot
    Q9BV40
    Related
    ENSP00000263864.5, ENST00000263864.10
    Conserved Domains (1) summary
    cd15868
    Location:1077
    R-SNARE_VAMP8; SNARE motif of VAMP8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85577535..85582031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005170.1XP_016860659.1  vesicle-associated membrane protein 8 isoform X1

    UniProtKB/TrEMBL
    B8ZZT4
    Related
    ENSP00000387094.1, ENST00000409760.1
    Conserved Domains (1) summary
    cl22856
    Location:1055
    SNARE; SNARE motif
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