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EIF3I eukaryotic translation initiation factor 3 subunit I [ Homo sapiens (human) ]

Gene ID: 8668, updated on 5-Sep-2021

Summary

Official Symbol
EIF3Iprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Iprovided by HGNC
Primary source
HGNC:HGNC:3272
See related
Ensembl:ENSG00000084623 MIM:603911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta
Expression
Ubiquitous expression in thyroid (RPKM 51.3), ovary (RPKM 48.1) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3I in Genome Data Viewer
Location:
1p35.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (32221584..32236170)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32687185..32697205)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 234 Neighboring gene IQ motif containing C Neighboring gene doublecortin domain containing 2B Neighboring gene myotubularin related protein 9 like, pseudogene Neighboring gene family with sequence similarity 167 member B Neighboring gene LCK proto-oncogene, Src family tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit I (EIF3I) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit I (EIF3I), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IC
Inferred by Curator
more info
PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit I
Names
TGF-beta receptor-interacting protein 1
TGFbeta receptor-interacting protein 1
eukaryotic translation initiation factor 3 subunit 2
eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa
predicted protein of HQ2242

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394168.1NP_001381097.1  eukaryotic translation initiation factor 3 subunit I isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL049795, AL121991
    Conserved Domains (2) summary
    sd00039
    Location:1450
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:6299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_003757.4NP_003748.1  eukaryotic translation initiation factor 3 subunit I isoform 1

    See identical proteins and their annotated locations for NP_003748.1

    Status: VALIDATED

    Source sequence(s)
    AL049795, AL121991
    Consensus CDS
    CCDS357.1
    UniProtKB/Swiss-Prot
    Q13347
    UniProtKB/TrEMBL
    Q5U0F4
    Related
    ENSP00000503348.1, ENST00000676801.1
    Conserved Domains (2) summary
    sd00039
    Location:1450
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:6311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    32221584..32236170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450518.1XP_024306286.1  eukaryotic translation initiation factor 3 subunit I isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:5894
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:34178
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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