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EIF3G eukaryotic translation initiation factor 3 subunit G [ Homo sapiens (human) ]

Gene ID: 8666, updated on 9-Feb-2020

Summary

Official Symbol
EIF3Gprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Gprovided by HGNC
Primary source
HGNC:HGNC:3274
See related
Ensembl:ENSG00000130811 MIM:603913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta
Summary
This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues See more
Orthologs

Genomic context

See EIF3G in Genome Data Viewer
Location:
19p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10115014..10119899, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10225690..10230599, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPAN-P2RY11 readthrough Neighboring gene Sharpr-MPRA regulatory region 3609 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog Neighboring gene purinergic receptor P2Y11 Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit G (EIF3G) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit G
Names
eukaryotic translation initiation factor 3 RNA-binding subunit
eukaryotic translation initiation factor 3 subunit p42
eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051197.1 RefSeqGene

    Range
    5026..9911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003755.5NP_003746.2  eukaryotic translation initiation factor 3 subunit G

    See identical proteins and their annotated locations for NP_003746.2

    Status: REVIEWED

    Source sequence(s)
    AA588881, BC000733
    Consensus CDS
    CCDS12227.1
    UniProtKB/Swiss-Prot
    O75821
    Related
    ENSP00000253108.3, ENST00000253108.9
    Conserved Domains (2) summary
    cd12933
    Location:62173
    eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
    cd12408
    Location:240316
    RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10115014..10119899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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