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EIF3F eukaryotic translation initiation factor 3 subunit F [ Homo sapiens (human) ]

Gene ID: 8665, updated on 7-Aug-2022

Summary

Official Symbol
EIF3Fprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Fprovided by HGNC
Primary source
HGNC:HGNC:3275
See related
Ensembl:ENSG00000175390 MIM:603914; AllianceGenome:HGNC:3275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT67; EIF3S5; eIF3-p47
Summary
Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3F in Genome Data Viewer
Location:
11p15.4
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7987337..8001852)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8066510..8081027)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8008884..8023399)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NLR family pyrin domain containing 10 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 5 Neighboring gene cancer susceptibility 23 Neighboring gene uncharacterized LOC124902627 Neighboring gene TUB bipartite transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit F (EIF3F) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit F (EIF3F) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit F
Names
deubiquitinating enzyme eIF3f
eIF-3-epsilon
eIF3-epsilon
eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD)
eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa
NP_003745.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003754.3NP_003745.1  eukaryotic translation initiation factor 3 subunit F

    See identical proteins and their annotated locations for NP_003745.1

    Status: VALIDATED

    Source sequence(s)
    AC116456, BC000490, CB141463, CD050033, U94855
    Consensus CDS
    CCDS7785.1
    UniProtKB/Swiss-Prot
    O00303, Q8N978
    Related
    ENSP00000499218.1, ENST00000651655.1
    Conserved Domains (1) summary
    cd08064
    Location:92354
    MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    7987337..8001852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    8066510..8081027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)