EIF3F eukaryotic translation initiation factor 3 subunit F [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF3Fprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 3 subunit Fprovided by HGNC
Primary source: HGNC:HGNC:3275
See related: Ensembl:ENSG00000175390 MIM:603914; AllianceGenome:HGNC:3275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRT67; EIF3S5; eIF3-p47
Summary: Enables identical protein binding activity and metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive intellectual developmental disorder 67. [provided by Alliance of Genome Resources, Mar 2025]
Expression: Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (7987337..8001852)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (8066510..8081027)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (8008884..8023399)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer.
Title: eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer.
EIF3F-related neurodevelopmental disorder: refining the phenotypic and expanding the molecular spectrum.
Title: EIF3F-related neurodevelopmental disorder: refining the phenotypic and expanding the molecular spectrum.
Study discovered a role of EIF3F-STAT3 interaction in the genetic control of cell migration and metastasis in human lung adenocarcinoma. EIF3F promotes lung cancer cell metastasis in vivo by regulating a cluster of 34 metastasis-promoting genes including Snail2. The interaction between EIF3F and STAT3 controlled the EIF3F-mediated increase in Snail2 expression and cellular invasion.
Title: Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.
results underscore the importance of estrogen-ERalpha-mediated control of eIF3f expression for the proliferation and survival of ER-positive breast cancer cells. These findings may provide rationale for the development of new therapies to treat ER-positive breast cancer.
Title: Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f).
The overexpression of eIF3f suppressed Akt and ERK signaling and subsequently depleted CLU expression. In addition, eIF3F stabilized p53, which increased the expression of p21 and Bax.
Title: eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells.
eIF3f/alpha adrenergic receptor interaction
Title: The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
Decreased expression of eukaryotic initiation factor 3f is associated with gastric cancer.
Title: Decreased expression of eukaryotic initiation factor 3f is an adverse prognostic factor for stage I-III gastric cancer.
eIF3f may play an important role in recurrence.
Title: Expression of eukaryotic initiation factor 3f is associated with prognosis in gastric carcinomas.
findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation
Title: The tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.
catalytically inactive forms of eIF3f as well as shRNAs targeting eIF3f repress Notch activation in a coculture assay, showing that eIF3f is a new positive regulator of the Notch pathway
Title: The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual developmental disorder, autosomal recessive 67 MedGen: C4749019 OMIM: 618295 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association scan of trait depression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit F (EIF3F) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit F (EIF3F) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80696 (e-PCR)
- UniSTS:89725

GDB:451583 (e-PCR)
- UniSTS:157318

GDB:451661 (e-PCR)
- UniSTS:157339

D11S1152 (e-PCR)
- UniSTS:19122

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal-dependent deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	IC Inferred by Curator more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	TAS Traceable Author Statement more info	PubMed
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in formation of cytoplasmic translation initiation complex	NAS Non-traceable Author Statement more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IC Inferred by Curator more info	PubMed
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	TAS Traceable Author Statement more info	PubMed
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit F

Names: deubiquitinating enzyme eIF3f; eIF-3-epsilon; eIF3-epsilon; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa

NP_003745.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.