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EIF3D eukaryotic translation initiation factor 3 subunit D [ Homo sapiens (human) ]

Gene ID: 8664, updated on 21-Jun-2020

Summary

Official Symbol
EIF3Dprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Dprovided by HGNC
Primary source
HGNC:HGNC:3278
See related
Ensembl:ENSG00000100353 MIM:603915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S7; eIF3-p66; eIF3-zeta
Summary
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 83.0), lymph node (RPKM 75.1) and 25 other tissues See more
Orthologs

Genomic context

See EIF3D in Genome Data Viewer
Location:
22q12.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (36510855..36529166, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36906897..36925277, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373020 Neighboring gene uncharacterized LOC105373019 Neighboring gene FAD dependent oxidoreductase domain containing 2 Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 pseudogene Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit D (EIF3D; eIF3-zeta), Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit D (EIF3D; eIF3-zeta), Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit D (EIF3D; eIF3-zeta), Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit D (EIF3D) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 3 subunit D (EIF3D; eIF3-zeta), Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 3, subunit D (EIF3D) at amino acid residues 120-121 by the HIV-1 protease PubMed
gag-pol HIV-1 PR cleaves eIF3D at amino acids 114/115 within the RNA binding domain (residues 86-118), leading to enhance HIV-1 replication PubMed
gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit D (EIF3D) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17258, MGC126526

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
cap-dependent translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of translation IPI
Inferred from Physical Interaction
more info
PubMed 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit D
Names
eIF3 p66
eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa
translation initiation factor eIF3 p66 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003753.4NP_003744.1  eukaryotic translation initiation factor 3 subunit D

    See identical proteins and their annotated locations for NP_003744.1

    Status: REVIEWED

    Source sequence(s)
    BC014912, BG718662
    Consensus CDS
    CCDS13930.1
    UniProtKB/Swiss-Prot
    O15371
    Related
    ENSP00000216190.8, ENST00000216190.13
    Conserved Domains (1) summary
    pfam05091
    Location:4521
    eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

RNA

  1. NR_156418.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL022313

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    36510855..36529166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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