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EIF3C eukaryotic translation initiation factor 3 subunit C [ Homo sapiens (human) ]

Gene ID: 8663, updated on 7-Jun-2020

Summary

Official Symbol
EIF3Cprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Cprovided by HGNC
Primary source
HGNC:HGNC:3279
See related
Ensembl:ENSG00000184110 MIM:603916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3CL; EIF3S8; eIF3-p110
Expression
Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues See more
Orthologs

Genomic context

See EIF3C in Genome Data Viewer
Location:
16p11.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28688558..28735730)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28699879..28747051)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984835 Neighboring gene sulfotransferase family 1A member 1 Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene cell division cycle 37 pseudogene 1 Neighboring gene microRNA 6862-2 Neighboring gene uncharacterized LOC105379464 Neighboring gene nuclear pore complex interacting protein family member B9 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene ribosomal protein S15a pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at five new loci associated with early-onset inflammatory bowel disease.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ53378, FLJ54400, FLJ54404, FLJ55450, FLJ55750, FLJ78287, MGC189737, MGC189744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of translation IPI
Inferred from Physical Interaction
more info
PubMed 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit C
Names
cell migration-inducing protein 17
eIF3 p110
eukaryotic translation initiation factor 3 subunit 8
eukaryotic translation initiation factor 3, subunit 8 (110kD)
eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037808.2NP_001032897.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001032897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AL045958, BC001571, BC071705, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000378953.1, ENST00000395587.5
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  2. NM_001199142.1NP_001186071.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001186071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AA679705, AK292155
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000457963.1, ENST00000566501.5
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  3. NM_001267574.2NP_001254503.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001254503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AK000739, AL045958, BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000457418.1, ENST00000566866.5
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  4. NM_001286478.1NP_001273407.1  eukaryotic translation initiation factor 3 subunit C isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC145285, AK303790, BC001571, DC341554
    Consensus CDS
    CCDS66993.1
    UniProtKB/Swiss-Prot
    Q99613
    Related
    ENSP00000456416.1, ENST00000564243.5
    Conserved Domains (2) summary
    smart00753
    Location:768856
    PAM; PCI/PINT associated module
    pfam05470
    Location:29695
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  5. NM_003752.5NP_003743.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_003743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000332604.6, ENST00000331666.10
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28688558..28735730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023814.2XP_016879303.1  eukaryotic translation initiation factor 3 subunit C isoform X1

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