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EIF3C eukaryotic translation initiation factor 3 subunit C [ Homo sapiens (human) ]

Gene ID: 8663, updated on 27-Nov-2024

Summary

Official Symbol
EIF3Cprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Cprovided by HGNC
Primary source
HGNC:HGNC:3279
See related
Ensembl:ENSG00000184110 MIM:603916; AllianceGenome:HGNC:3279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3CL; EIF3S8; eIF3-p110
Summary
Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of translation and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3C in Genome Data Viewer
Location:
16p11.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28688558..28735730)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28969279..29016311)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28699879..28747051)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28677654-28678567 Neighboring gene small nucleolar RNA U13 Neighboring gene cell division cycle 37 pseudogene 1 Neighboring gene microRNA 6862-2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28742791-28743343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28751627-28752170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28752171-28752713 Neighboring gene uncharacterized LOC124903761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28770347-28770847 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene nuclear pore complex interacting protein family member B9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variants at five new loci associated with early-onset inflammatory bowel disease.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ53378, FLJ54400, FLJ54404, FLJ55450, FLJ55750, FLJ78287, MGC189737, MGC189744

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit C
Names
cell migration-inducing protein 17
eukaryotic translation initiation factor 3 subunit 8
eukaryotic translation initiation factor 3, subunit 8 (110kD)
eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037808.2NP_001032897.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001032897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AL045958, BC001571, BC071705, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000378953.1, ENST00000395587.5
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  2. NM_001199142.1NP_001186071.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001186071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AA679705, AK292155
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000457963.1, ENST00000566501.5
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  3. NM_001267574.2NP_001254503.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001254503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AK000739, AL045958, BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000457418.1, ENST00000566866.5
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  4. NM_001286478.1NP_001273407.1  eukaryotic translation initiation factor 3 subunit C isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC145285, AK303790, BC001571, DC341554
    Consensus CDS
    CCDS66993.1
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000456416.1, ENST00000564243.5
    Conserved Domains (2) summary
    smart00753
    Location:768856
    PAM; PCI/PINT associated module
    pfam05470
    Location:29695
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  5. NM_003752.5NP_003743.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_003743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
    UniProtKB/TrEMBL
    A1KYQ7
    Related
    ENSP00000332604.7, ENST00000331666.11
    Conserved Domains (2) summary
    smart00088
    Location:778866
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28688558..28735730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434828.1XP_047290784.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
  2. XM_047434827.1XP_047290783.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
  3. XM_017023814.3XP_016879303.1  eukaryotic translation initiation factor 3 subunit C isoform X2

    UniProtKB/TrEMBL
    A1KYQ7
  4. XM_047434829.1XP_047290785.1  eukaryotic translation initiation factor 3 subunit C isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28969279..29016311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314249.1XP_054170224.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/Swiss-Prot
    A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
  2. XM_054314250.1XP_054170225.1  eukaryotic translation initiation factor 3 subunit C isoform X3