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TNKS tankyrase [ Homo sapiens (human) ]

Gene ID: 8658, updated on 23-Nov-2023

Summary

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Official Symbol
TNKSprovided by HGNC
Official Full Name
tankyraseprovided by HGNC
Primary source
HGNC:HGNC:11941
See related
Ensembl:ENSG00000173273 MIM:603303; AllianceGenome:HGNC:11941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a
Summary
Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.6), brain (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TNKS in Genome Data Viewer
Location:
8p23.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (9555912..9782346)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (9959097..10187973, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (9413422..9639856)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379231 Neighboring gene uncharacterized LOC124901884 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:9240606-9241805 Neighboring gene DENN domain containing 4A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26983 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:9413105-9413766 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:9413767-9414426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26988 Neighboring gene microRNA 597 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124902056

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers. Duan X, et al. Ecotoxicol Environ Saf, 2023 Jan 15. PMID 36603485
  2. Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner. Yue X, et al. Commun Biol, 2021 Dec 7. PMID 34876695, Free PMC Article
  3. Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor. Ryu H, et al. Int J Mol Sci, 2021 Jul 8. PMID 34298950, Free PMC Article
  4. Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema. Miglani M, et al. Hum Mol Genet, 2020 Nov 4. PMID 32916703
  5. circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS. Ma Z, et al. Cell Death Dis, 2020 May 11. PMID 32393760, Free PMC Article

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers.
    Title: Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers.
  2. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
    Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
  3. Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma.
    Title: Deubiquitination of TNKS1 Regulates Wnt/β-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma.
  4. Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.
    Title: Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.
  5. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines.
    Title: Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines.
  6. Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema.
    Title: Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema.
  7. Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
    Title: Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
  8. Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor.
    Title: Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor.
  9. Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
    Title: Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
  10. circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.
    Title: circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
EBI GWAS Catalog
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
  
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of telomeric DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
  
involved_in positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomere capping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein poly-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of telomere maintenance via telomerase TAS
Traceable Author Statement
more info
 PubMed 
involved_in spindle assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of nuclear pore TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
poly [ADP-ribose] polymerase tankyrase-1
Names
ADP-ribosyltransferase diphtheria toxin-like 5
TANK1
TNKS-1
TRF1-interacting ankyrin-related ADP-ribose polymerase 1
poly [ADP-ribose] polymerase 5A
protein poly-ADP-ribosyltransferase tankyrase-1
tankyrase I
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase-1
NP_003738.2
XP_011542147.1
XP_011542148.1
XP_054188244.1
XP_054188245.1
XP_054188246.1
XP_054188247.1
XP_054188248.1
XP_054217405.1
XP_054217406.1
XP_054217407.1
XP_054217408.1
XP_054217409.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003747.3 → NP_003738.2  poly [ADP-ribose] polymerase tankyrase-1

    See identical proteins and their annotated locations for NP_003738.2

    Status: VALIDATED

    Source sequence(s)
    AC021242, AC103834, AC103877, AC104052
    Consensus CDS
    CCDS5974.1
    UniProtKB/Swiss-Prot
    O95271, O95272, Q4G0F2, Q59FX0
    UniProtKB/TrEMBL
    E7EQ52
    Related
    ENSP00000311579.6, ENST00000310430.11
    Conserved Domains (8) summary
    cd09524
    Location:1024 → 1089
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:1030 → 1087
    SAM; Sterile alpha motif
    cd00204
    Location:676 → 801
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:1091 → 1313
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:1105 → 1308
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:688 → 780
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:803 → 857
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:371 → 399
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    9555912..9782346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543845.4 → XP_011542147.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X1

    See identical proteins and their annotated locations for XP_011542147.1

    UniProtKB/TrEMBL
    E7EQ52
    Related
    ENSP00000428185.2, ENST00000517770.2
    Conserved Domains (6) summary
    PTZ00322
    Location:177 → 269
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02876
    Location:231 → 616
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:1024 → 1089
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:652 → 976
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:1091 → 1299
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:371 → 399
    ANK; ANK repeat [structural motif]

  2. XM_011543846.4 → XP_011542148.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X2

    UniProtKB/TrEMBL
    E7EQ52
    Conserved Domains (6) summary
    PTZ00322
    Location:177 → 269
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02876
    Location:231 → 616
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:1024 → 1089
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:652 → 976
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:1091 → 1299
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:371 → 399
    ANK; ANK repeat [structural motif]

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    3566718..3795557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332271.1 → XP_054188246.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X3

    UniProtKB/TrEMBL
    E7EQ52

  2. XM_054332273.1 → XP_054188248.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X5

    UniProtKB/TrEMBL
    E7EQ52

  3. XM_054332272.1 → XP_054188247.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X4

  4. XM_054332270.1 → XP_054188245.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X2

    UniProtKB/TrEMBL
    E7EQ52

  5. XM_054332269.1 → XP_054188244.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X1

    UniProtKB/TrEMBL
    E7EQ52

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    9959097..10187973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361432.1 → XP_054217407.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X6

    UniProtKB/TrEMBL
    E7EQ52

  2. XM_054361434.1 → XP_054217409.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X8

    UniProtKB/TrEMBL
    E7EQ52

  3. XM_054361433.1 → XP_054217408.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X7

  4. XM_054361431.1 → XP_054217406.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X2

    UniProtKB/TrEMBL
    E7EQ52

  5. XM_054361430.1 → XP_054217405.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X1

    UniProtKB/TrEMBL
    E7EQ52
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95271.2 GenPept UniProtKB/Swiss-Prot:O95271

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