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NS1 nonstructural protein 1 [ Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) ]

Gene ID: 8656648, updated on 10-May-2025
Gene symbol
NS1
Gene description
nonstructural protein 1
Locus tag
FLUAVH5N1_s8gp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) (strain: A/goose/Guangdong/1/1996, serotype: H5N1)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus; Alphainfluenzavirus influenzae
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Location:
segment: 8
Sequence:
NC_007364.1 (15..707)

NC_007364.1Genomic Context describing neighboring genes Neighboring gene nonstructural protein 2

Genomic Sequence:
NC_007364.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding. Wang X, et al. Vet Microbiol, 2020 Dec. PMID 33126184
  2. Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein. Zielecki F, et al. J Virol, 2010 Oct. PMID 20686040, Free PMC Article
  3. Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus. Fan S, et al. J Virol, 2013 May. PMID 23408626, Free PMC Article
  4. Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1. Kato YS, et al. Protein Pept Lett, 2016. PMID 26845765
  5. Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus. Ma Y, et al. BMC Microbiol, 2017 Sep 11. PMID 28893180, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity.
    Title: Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity.
  2. The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding.
    Title: The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding.
  3. Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian NS1 protein has been reported.
    Title: Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.
  4. study demonstrated that the amino acid at positions 55, 66, and 133 of NS1 play an important role in the ability of H5N1 influenza viruses to dampen the host IFN response
    Title: Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells.
  5. ANXA2 interacts with NS1 and ANXA2 expression increases highly pathogenic H5N1 avian influenza virus replication.
    Title: Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus.
  6. Studies showed that the replacement of the 42nd residue of NS1 has a direct impact on the binding to dsRNA, so that the 42nd residue should be responsible for the high pathogenicity of H5N1. The structural models also suggested that the replacement causes structural change within the RNA-binding domain , leading to the change in the dsRNA-binding affinity.
    Title: Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.
  7. analysis yielded chicken gga-miR-1658* as the potential miRNA which is targeting the NS1 gene of H5N1 genome
    Title: In-silico search of virus-specific host microRNAs regulating avian influenza virus NS1 expression.
  8. D120 and R195 of H5N1 influenza virus NS1 were crucial for the binding to host NOLC1.
    Title: Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
  9. This is the first report to elucidate the novel function of NS1--binding protein collaborating with viral protein NS1 in modulation of host cell physiology. In addition, an alternative role of adaptor protein CRKL in association with NS1 and NS1-BP during influenza A virus infection is demonstrated.
    Title: NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL.
  10. H5N1 viral NS1 interacts with host NOLC1 protein.
    Title: Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Homology

Preferred Names
nonstructural protein 1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007364.1 Reference assembly

    Range
    15..707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_308673.1 nonstructural protein 1 [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]

    See identical proteins and their annotated locations for YP_308673.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Q0L6
    UniProtKB/TrEMBL
    B1MPQ7, D1LMQ9, Q91R63, Q9EA66
    Conserved Domains (1) summary
    pfam00600
    Location:1 → 216
    Flu_NS1; Influenza non-structural protein (NS1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Q0L6.1

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