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AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ]

Gene ID: 8644, updated on 12-Jul-2020

Summary

Official Symbol
AKR1C3provided by HGNC
Official Full Name
aldo-keto reductase family 1 member C3provided by HGNC
Primary source
HGNC:HGNC:386
See related
Ensembl:ENSG00000196139 MIM:603966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in duodenum (RPKM 122.7), gall bladder (RPKM 91.1) and 15 other tissues See more
Orthologs

Genomic context

See AKR1C3 in Genome Data Viewer
Location:
10p15.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (5048766..5107686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5090958..5149878)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928051 Neighboring gene aldo-keto reductase family 1 member C2 Neighboring gene CRISPRi-validated cis-regulatory element chr10.193 Neighboring gene uncharacterized LOC107984198 Neighboring gene aldo-keto reductase family 1 member C8, pseudogene Neighboring gene aldo-keto reductase family 1 member C4 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
NADP-retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
alcohol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alditol:NADP+ 1-oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
aldo-keto reductase (NADP) activity TAS
Traceable Author Statement
more info
PubMed 
androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
androsterone dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delta4-3-oxosteroid 5beta-reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
dihydrotestosterone 17-beta-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
geranylgeranyl reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
indanol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
ketoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ketosteroid monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
phenanthrene 9,10-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin D2 11-ketoreductase activity TAS
Traceable Author Statement
more info
 
prostaglandin H2 endoperoxidase reductase activity TAS
Traceable Author Statement
more info
 
prostaglandin-F synthase activity IEA
Inferred from Electronic Annotation
more info
 
retinal dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
testosterone 17-beta-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
testosterone dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
C21-steroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to corticosteroid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to jasmonic acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to prostaglandin D stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to prostaglandin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
daunorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
doxorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
farnesol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
keratinocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
macromolecule metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
progesterone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
prostaglandin metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal absorption NAS
Non-traceable Author Statement
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aldo-keto reductase family 1 member C3
Names
3-alpha hydroxysteroid dehydrogenase, type II
3-alpha-HSD type II, brain
chlordecone reductase homolog HAKRb
dihydrodiol dehydrogenase 3
dihydrodiol dehydrogenase X
indanol dehydrogenase
prostaglandin F synthase
testosterone 17-beta-dehydrogenase 5
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
type IIb 3-alpha hydroxysteroid dehydrogenase
NP_001240837.1
NP_001240838.1
NP_003730.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047094.1 RefSeqGene

    Range
    5001..63921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001253908.1NP_001240837.1  aldo-keto reductase family 1 member C3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is the same length as isoform 1 but differs by 1 aa in the N-terminus.
    Source sequence(s)
    BC019230, BG547635, H79159
    Consensus CDS
    CCDS73062.1
    UniProtKB/Swiss-Prot
    P42330
    UniProtKB/TrEMBL
    A0A0A0MSS8
    Related
    ENSP00000401327.3, ENST00000439082.7
    Conserved Domains (2) summary
    COG0656
    Location:9305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:17297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. NM_001253909.2NP_001240838.1  aldo-keto reductase family 1 member C3 isoform 3

    See identical proteins and their annotated locations for NP_001240838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons at its 3' end, which extends into an intron compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK296701, AL391427
    UniProtKB/TrEMBL
    B4DKT3
    Related
    ENST00000480697.6
    Conserved Domains (2) summary
    COG0656
    Location:8134
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:17119
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  3. NM_003739.6NP_003730.4  aldo-keto reductase family 1 member C3 isoform 1

    See identical proteins and their annotated locations for NP_003730.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes one of the larger isoforms (1).
    Source sequence(s)
    AV761799, BC019230
    Consensus CDS
    CCDS7063.1
    UniProtKB/Swiss-Prot
    P42330
    Related
    ENSP00000369927.3, ENST00000380554.5
    Conserved Domains (1) summary
    COG0656
    Location:8305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    5048766..5107686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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