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OASL 2'-5'-oligoadenylate synthetase like [ Homo sapiens (human) ]

Gene ID: 8638, updated on 6-Jan-2019

Summary

Official Symbol
OASLprovided by HGNC
Official Full Name
2'-5'-oligoadenylate synthetase likeprovided by HGNC
Primary source
HGNC:HGNC:8090
See related
Ensembl:ENSG00000135114 MIM:603281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
Expression
Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues See more
Orthologs

Genomic context

See OASL in Genome Data Viewer
Location:
12q24.31
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (121018882..121039242, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121458095..121477045, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HNF1A antisense RNA 1 Neighboring gene HNF1 homeobox A Neighboring gene chromosome 12 open reading frame 43 Neighboring gene uncharacterized LOC105378258 Neighboring gene uncharacterized LOC105370031

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
NHGRI GWA Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
NHGRI GWA Catalog
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
NHGRI GWA Catalog
New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
NHGRI GWA Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of 2'-5'-oligoadenylate synthetase-like (OASL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of 2'-5'-oligoadenylate synthetase-like (OASL; p59-OASL) in immature dendritic cells and monocyte-derived macrophages PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of OASL in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
    Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus TAS
Traceable Author Statement
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
2'-5'-oligoadenylate synthase-like protein
Names
2'-5'-OAS-RP
2'-5'-OAS-related protein
59 kDa 2'-5'-oligoadenylate synthase-like protein
59 kDa 2'-5'-oligoadenylate synthetase-like protein
TR-interacting protein 14
thyroid receptor-interacting protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261825.1NP_001248754.1  2'-5'-oligoadenylate synthase-like protein isoform c

    See identical proteins and their annotated locations for NP_001248754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AW069118, DB005346, JQ792168
    Consensus CDS
    CCDS73536.1
    UniProtKB/Swiss-Prot
    Q15646
    Related
    ENSP00000479512.1, ENST00000620239.4
    Conserved Domains (5) summary
    cd05400
    Location:29212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    smart00213
    Location:304372
    UBQ; Ubiquitin homologues
    pfam00240
    Location:309375
    ubiquitin; Ubiquitin family
    pfam10421
    Location:167219
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl00155
    Location:224303
    UBQ; Ubiquitin-like proteins
  2. NM_003733.3NP_003724.1  2'-5'-oligoadenylate synthase-like protein isoform a

    See identical proteins and their annotated locations for NP_003724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK314419, AW069118, DB005346, JQ792168
    Consensus CDS
    CCDS9211.1
    UniProtKB/Swiss-Prot
    Q15646
    Related
    ENSP00000257570.4, ENST00000257570.9
    Conserved Domains (4) summary
    cd05400
    Location:29212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    cd01811
    Location:354433
    OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
    pfam00240
    Location:436506
    ubiquitin; Ubiquitin family
    pfam10421
    Location:168351
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  3. NM_198213.2NP_937856.1  2'-5'-oligoadenylate synthase-like protein isoform b

    See identical proteins and their annotated locations for NP_937856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AW069118, BG339739, BM909951, DB005346, JQ792168
    Consensus CDS
    CCDS9212.1
    UniProtKB/Swiss-Prot
    Q15646
    Related
    ENSP00000341125.5, ENST00000339275.9
    Conserved Domains (2) summary
    cd05400
    Location:29212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:167219
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    121018882..121039242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020140.1XP_016875629.1  2'-5'-oligoadenylate synthase-like protein isoform X1

  2. XM_017020141.1XP_016875630.1  2'-5'-oligoadenylate synthase-like protein isoform X2

    UniProtKB/Swiss-Prot
    Q15646
    Conserved Domains (2) summary
    cd05400
    Location:29212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:167219
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
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