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RNASET2 ribonuclease T2 [ Homo sapiens (human) ]

Gene ID: 8635, updated on 20-Dec-2019

Summary

Official Symbol
RNASET2provided by HGNC
Official Full Name
ribonuclease T2provided by HGNC
Primary source
HGNC:HGNC:21686
See related
Ensembl:ENSG00000026297 MIM:612944
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNASE6PL; bA514O12.3
Summary
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 93.0), colon (RPKM 39.0) and 24 other tissues See more
Orthologs

Genomic context

See RNASET2 in Genome Data Viewer
Location:
6q27
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (166922113..166956580, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (167342992..167370077, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase A2 Neighboring gene insulin like growth factor 2 mRNA binding protein 3 pseudogene Neighboring gene RPS6KA2 antisense RNA 1 Neighboring gene protein GVQW1-like Neighboring gene CRISPRi-validated cis-regulatory element chr6.5886 Neighboring gene uncharacterized LOC105378120

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Leukoencephalopathy, cystic, without megalencephaly
MedGen: C2751843 OMIM: 612951 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies two new risk loci for Graves' disease.
NHGRI GWA Catalog
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
NHGRI GWA Catalog
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
NHGRI GWA Catalog
Genome-wide association study of endometrial cancer in E2C2.
NHGRI GWA Catalog
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal lumen IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease T2
Names
ribonuclease 6
NP_003721.2
XP_016866886.1
XP_016866887.1
XP_016866888.1
XP_024302343.1
XP_024302344.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016280.2 RefSeqGene

    Range
    5040..39477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003730.6NP_003721.2  ribonuclease T2 precursor

    See identical proteins and their annotated locations for NP_003721.2

    Status: REVIEWED

    Source sequence(s)
    AL133458, AL159163
    Consensus CDS
    CCDS5295.1
    UniProtKB/Swiss-Prot
    O00584
    Related
    ENSP00000426455.1, ENST00000508775.5
    Conserved Domains (1) summary
    cd01061
    Location:34227
    RNase_T2_euk; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    166922113..166956580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446575.1XP_024302343.1  ribonuclease T2 isoform X2

    Conserved Domains (1) summary
    cl00208
    Location:1135
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...
  2. XM_017011399.1XP_016866888.1  ribonuclease T2 isoform X3

  3. XM_017011398.1XP_016866887.1  ribonuclease T2 isoform X2

    Conserved Domains (1) summary
    cl00208
    Location:1135
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...
  4. XM_017011397.1XP_016866886.1  ribonuclease T2 isoform X1

    UniProtKB/TrEMBL
    D6REQ6
    Related
    ENSP00000424947.1, ENST00000366855.10
    Conserved Domains (1) summary
    pfam00445
    Location:1167
    Ribonuclease_T2; Ribonuclease T2 family
  5. XM_024446576.1XP_024302344.1  ribonuclease T2 isoform X2

    Conserved Domains (1) summary
    cl00208
    Location:1135
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...
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