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UNC5C unc-5 netrin receptor C [ Homo sapiens (human) ]

Gene ID: 8633, updated on 23-Nov-2021

Summary

Official Symbol
UNC5Cprovided by HGNC
Official Full Name
unc-5 netrin receptor Cprovided by HGNC
Primary source
HGNC:HGNC:12569
See related
Ensembl:ENSG00000182168 MIM:603610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC5H3
Summary
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues See more
Orthologs
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Genomic context

See UNC5C in Genome Data Viewer
Location:
4q22.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (95162504..95549210, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (96083655..96470124, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BMPR1B divergent transcript Neighboring gene bone morphogenetic protein receptor type 1B Neighboring gene uncharacterized LOC105377337 Neighboring gene UNC5C antisense RNA 1 Neighboring gene ribosomal protein L30 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
GeneReviews: Not available
Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables netrin receptor activity involved in chemorepulsion ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in chemorepulsion of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dorsal root ganglion development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
netrin receptor UNC5C
Names
protein unc-5 homolog 3
protein unc-5 homolog C
unc-5 homolog 3
unc-5 homolog C
unc5 (C.elegans homolog) c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003728.4NP_003719.3  netrin receptor UNC5C precursor

    See identical proteins and their annotated locations for NP_003719.3

    Status: REVIEWED

    Source sequence(s)
    AC098584, AC105395, AC106881
    Consensus CDS
    CCDS3643.1
    UniProtKB/Swiss-Prot
    O95185
    UniProtKB/TrEMBL
    A8K385
    Related
    ENSP00000406022.1, ENST00000453304.6
    Conserved Domains (5) summary
    smart00218
    Location:528631
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:263314
    TSP1; Thrombospondin type 1 repeats
    cd08799
    Location:844926
    Death_UNC5C; Death domain found in Uncoordinated-5C
    pfam17217
    Location:678817
    UPA; UPA domain
    cl11960
    Location:171257
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    95162504..95549210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263321.3XP_005263378.1  netrin receptor UNC5C isoform X1

    See identical proteins and their annotated locations for XP_005263378.1

    Conserved Domains (5) summary
    smart00218
    Location:547650
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:263314
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:169257
    I-set; Immunoglobulin I-set domain
    cd08799
    Location:863945
    Death_UNC5C; Death domain found in Uncoordinated-5C
    cl11960
    Location:171257
    Ig; Immunoglobulin domain
  2. XM_017008789.1XP_016864278.1  netrin receptor UNC5C isoform X2

  3. XM_017008790.1XP_016864279.1  netrin receptor UNC5C isoform X2

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