U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mhkA Alpha kinase family protein [ Dictyostelium discoideum AX4 ]

Gene ID: 8628066, updated on 23-Apr-2026
Official Symbol
mhkA
Official Full Name
Alpha kinase family protein
Primary source
dictyBase:DDB_G0291231
Locus tag
DDB_G0291231
See related
AmoebaDB:DDB_G0291231; VEuPathDB:DDB_G0291231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0183797; DDBDRAFT_0216274; DDB_0183797; DDB_0216274
Try the new Gene page
Try the new Transcripts and proteins table
See mhkA in Genome Data Viewer
Location:
chromosome: 6
Exon count:
1
Sequence:
Chromosome: 6; NC_007092.3 (65139..68579)

Chromosome 6 - NC_007092.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein 184D Neighboring gene hypothetical protein Neighboring gene cellulose-binding domain-containing protein Neighboring gene Rab GTPase

Genomic Sequence:
NC_007092.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly. Egelhoff TT, et al. J Biol Chem, 2005 Jan 28. PMID 15545285
  2. Dictyostelium myosin II heavy-chain kinase A is activated by autophosphorylation: studies with Dictyostelium myosin II and synthetic peptides. Medley QG, et al. Biochemistry, 1990 Sep 25. PMID 2176841
  3. Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum. Côte GP, et al. J Biol Chem, 1987 Jan 25. PMID 3027076
  4. Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins. Futey LM, et al. J Biol Chem, 1995 Jan 13. PMID 7822274
  5. Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development. Kolman MF, et al. J Cell Biol, 1996 Jan. PMID 8567716, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ADP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin II binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin heavy chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin heavy chain kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin heavy chain kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myosin II filament disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myosin II filament disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in myosin II filament disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Alpha kinase family protein
Names
MHCK subfamily protein kinase
myosin heavy chain kinase
protein kinase, Atypical group
protein serine/threonine kinase

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007092.3 Reference assembly

    Range
    65139..68579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_630027.1 → XP_635119.1  myosin heavy chain kinase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_635119.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P42527, Q54EX1
    Conserved Domains (6) summary
    smart00811
    Location:568 → 800
    Alpha_kinase; Alpha-kinase family
    COG2319
    Location:803 → 1146
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:861 → 1142
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04880
    Location:448 → 531
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam07889
    Location:191 → 242
    DUF1664; Protein of unknown function (DUF1664)
    sd00039
    Location:874 → 910
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials