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roco4 ROCO family protein kinase [ Dictyostelium discoideum AX4 ]

Gene ID: 8626525, updated on 23-Apr-2026
Official Symbol
roco4
Official Full Name
ROCO family protein kinase
Primary source
dictyBase:DDB_G0288251
Locus tag
DDB_G0288251
See related
AmoebaDB:DDB_G0288251; VEuPathDB:DDB_G0288251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0187846; DDBDRAFT_0191509; DDB_0187846; DDB_0191509
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See roco4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_007091.3 (1284583..1289862)

Chromosome 5 - NC_007091.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene histone-lysine N-methyltransferase Neighboring gene G-protein-coupled receptor family protein Neighboring gene G-protein-coupled receptor family protein

Genomic Sequence:
NC_007091.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity. Rosenbusch KE, et al. Front Cell Dev Biol, 2021. PMID 34568343, Free PMC Article
  2. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Gilsbach BK, et al. Proc Natl Acad Sci U S A, 2012 Jun 26. PMID 22689969, Free PMC Article
  3. Characterization of the Roco protein family in Dictyostelium discoideum. van Egmond WN, et al. Eukaryot Cell, 2010 May. PMID 20348387, Free PMC Article
  4. The genome of the social amoeba Dictyostelium discoideum. Eichinger L, et al. Nature, 2005 May 5. PMID 15875012, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial electron transport, NADH to ubiquinone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phototaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sorocarp stalk development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sorocarp stalk development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ROCO family protein kinase
Names
leucine-rich repeat-containing protein
protein kinase, TKL group
tyrosine kinase-like protein
XP_636808.1
  • Similar to LRR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007091.3 Reference assembly

    Range
    1284583..1289862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_631716.1 → XP_636808.1  leucine-rich repeat-containing protein [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_636808.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q54J79, Q6XHB2
    Conserved Domains (10) summary
    cd09914
    Location:370 → 540
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG2319
    Location:1436 → 1717
    WD40; WD40 repeat [General function prediction only]
    COG4886
    Location:258 → 368
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd13999
    Location:1032 → 1289
    STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
    sd00031
    Location:258 → 280
    LRR_1; leucine-rich repeat [structural motif]
    pfam00071
    Location:372 → 543
    Ras; Ras family
    pfam07714
    Location:1026 → 1289
    Pkinase_Tyr; Protein tyrosine kinase
    pfam16095
    Location:595 → 787
    COR; C-terminal of Roc, COR, domain
    sd00039
    Location:1511 → 1545
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:1443 → 1661
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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