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mhcA myosin II heavy chain [ Dictyostelium discoideum AX4 ]

Gene ID: 8625606, updated on 11-Jun-2025
Official Symbol
mhcA
Official Full Name
myosin II heavy chain
Primary source
dictyBase:DDB_G0286355
Locus tag
DDB_G0286355
See related
AmoebaDB:DDB_G0286355; VEuPathDB:DDB_G0286355
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0186963; DDBDRAFT_0191444; DDB_0186963; DDB_0191444
NEW
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See mhcA in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Sequence:
Chromosome: 4; NC_007090.3 (4451077..4457427)

Chromosome 4 - NC_007090.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene WD40 repeat-containing protein

Genomic Sequence:
NC_007090.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Computer-assisted analysis of filopod formation and the role of myosin II heavy chain phosphorylation in Dictyostelium. Heid PJ, et al. J Cell Sci, 2005 May 15. PMID 15855234
  2. PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells. Pramanik MK, et al. Genes Cells, 2009 Jul. PMID 19515202
  3. Visualizing myosin-actin interaction with a genetically-encoded fluorescent strain sensor. Iwai S, et al. Proc Natl Acad Sci U S A, 2008 Nov 4. PMID 18971336, Free PMC Article
  4. Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR. Klein JC, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18725645, Free PMC Article
  5. Actin-based propulsive forces and myosin-II-based contractile forces in migrating Dictyostelium cells. Iwadate Y, et al. J Cell Sci, 2008 Apr 15. PMID 18388319

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation and plasticity of catalysis in myosin II are reported based on insights from the analysis of mechanochemical coupling in this protein.
    Title: Regulation and Plasticity of Catalysis in Enzymes: Insights from Analysis of Mechanochemical Coupling in Myosin.
  2. Switch 1 loop movement in myosin II determines actin interaction.
    Title: Reversible movement of switch 1 loop of myosin determines actin interaction.
  3. a structural transition in the Dictyostelium myosin II relay helix during the actin-activated power stroke, is reported.
    Title: Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain.
  4. Myosin heads bound to oriented actin filaments are highly disordered with respect to the actin filament axis, in contrast to the nearly crystalline order of myosin heads in rigor.
    Title: Conformationally trapping the actin-binding cleft of myosin with a bifunctional spin label.
  5. Oxidation-induced structural change in myosin includes a redistribution of existing structural states of the actin-binding cleft.
    Title: Structural and functional impact of site-directed methionine oxidation in myosin.
  6. analysis of the structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V
    Title: Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V.
  7. These results demonstrate that the PP2A B subunits phr2aBalpha and phr2aBbeta contribute to myosin II assembly control in vivo, with phr2aBalpha having the predominant role facilitating MHC dephosphorylation to facilitate filament assembly.
    Title: Role of B regulatory subunits of protein phosphatase type 2A in myosin II assembly control in Dictyostelium discoideum.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables adenyl nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin-myosin filament sliding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aggregation involved in sorocarp development IEA
Inferred from Electronic Annotation
more info
  
involved_in aggregation involved in sorocarp development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within bleb assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in contractile actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in contractile vacuole organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in culmination involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic actin-based contraction involved in forward cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hypotonic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myosin filament assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudopodium retraction IEA
Inferred from Electronic Annotation
more info
  
involved_in pseudopodium retraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to differentiation-inducing factor 1 HDA PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in substrate-dependent cell migration, cell extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uropod retraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actomyosin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell trailing edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early phagosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in equatorial cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix HDA PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pathogen-containing vacuole HDA PubMed 
located_in phagocytic cup base IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in uropod IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
myosin II heavy chain
Names
myosin heavy chain

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007090.3 Reference assembly

    Range
    4451077..4457427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_632648.1 → XP_637740.1  myosin II heavy chain [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_637740.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08799, Q54LU0
    Conserved Domains (6) summary
    cd01377
    Location:100 → 747
    MYSc_class_II; class II myosins, motor domain
    pfam00063
    Location:88 → 747
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:1037 → 2018
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:33 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam06273
    Location:1288 → 1368
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    pfam15743
    Location:1347 → 1495
    SPATA1_C; Spermatogenesis-associated C-terminus
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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