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ASMTL acetylserotonin O-methyltransferase like [ Homo sapiens (human) ]

Gene ID: 8623, updated on 11-Sep-2019

Summary

Official Symbol
ASMTLprovided by HGNC
Official Full Name
acetylserotonin O-methyltransferase likeprovided by HGNC
Primary source
HGNC:HGNC:751
See related
Ensembl:ENSG00000169093 MIM:300162; MIM:400011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASTML; ASMTLX; ASMTLY
Summary
The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in ovary (RPKM 11.8), prostate (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See ASMTL in Genome Data Viewer
Location:
Xp22.33 and Yp11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (1403139..1453794, complement)
109.20190905 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (1403139..1453794, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1522032..1572687, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1472032..1522687, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373102 Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene P2Y receptor family member 8 Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373102 Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene P2Y receptor family member 8 Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADH pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
nucleoside-triphosphate diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein
Names
N-acetylserotonin O-methyltransferase-like protein
acetylserotonin N-methyltransferase-like
NP_001166944.1
NP_001166945.1
NP_004183.2
XP_005274491.1
XP_005274840.1
XP_011543940.1
XP_011544487.1
XP_016885408.1
XP_016885573.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016772.1 RefSeqGene

    Range
    5854..55624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173473.1NP_001166944.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK225770, AK301844, BM129217, BU688748, DA904467
    Consensus CDS
    CCDS55362.1
    UniProtKB/Swiss-Prot
    O95671
    Related
    ENSP00000446410.1, ENST00000534940.6
    Conserved Domains (3) summary
    cd00555
    Location:1150
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:229313
    Dimerisation2; Dimerization domain
    cl17173
    Location:330546
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001173474.2NP_001166945.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 3

    See identical proteins and their annotated locations for NP_001166945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK090498, AK225770, AK301844, BM129217, BU688748
    Consensus CDS
    CCDS55363.1
    UniProtKB/Swiss-Prot
    O95671
    Related
    ENSP00000370734.4, ENST00000381333.9
    Conserved Domains (3) summary
    cd00555
    Location:15192
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:271355
    Dimerisation2; Dimerization domain
    cl17173
    Location:372588
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_004192.4NP_004183.2  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 1

    See identical proteins and their annotated locations for NP_004183.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)
    Source sequence(s)
    AK001090, AK225770, AK301844, BM129217, BU688748, DA005122
    Consensus CDS
    CCDS43917.1
    UniProtKB/Swiss-Prot
    O95671
    UniProtKB/TrEMBL
    B3KM43
    Related
    ENSP00000370718.3, ENST00000381317.9
    Conserved Domains (3) summary
    cd00555
    Location:15208
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:287371
    Dimerisation2; Dimerization domain
    cl17173
    Location:388604
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    1403139..1453794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274434.3XP_005274491.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X1

    See identical proteins and their annotated locations for XP_005274491.1

    UniProtKB/Swiss-Prot
    O95671
    Conserved Domains (3) summary
    cd00555
    Location:15208
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:287371
    Dimerisation2; Dimerization domain
    cl17173
    Location:388604
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017029919.2XP_016885408.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X3

  3. XM_011546185.2XP_011544487.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X2

    See identical proteins and their annotated locations for XP_011544487.1

    Conserved Domains (3) summary
    cd00555
    Location:9125
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:204288
    Dimerisation2; Dimerization domain
    cl17173
    Location:305521
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    1403139..1453794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274783.3XP_005274840.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X1

    See identical proteins and their annotated locations for XP_005274840.1

    UniProtKB/Swiss-Prot
    O95671
    Conserved Domains (3) summary
    cd00555
    Location:15208
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:287371
    Dimerisation2; Dimerization domain
    cl17173
    Location:388604
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017030084.2XP_016885573.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X3

  3. XM_011545638.2XP_011543940.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X2

    See identical proteins and their annotated locations for XP_011543940.1

    Conserved Domains (3) summary
    cd00555
    Location:9125
    Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
    pfam16864
    Location:204288
    Dimerisation2; Dimerization domain
    cl17173
    Location:305521
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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