U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pah phenylalanine 4-monooxygenase [ Dictyostelium discoideum AX4 ]

Gene ID: 8621691, updated on 3-Jun-2026
Official Symbol
pah
Official Full Name
phenylalanine 4-monooxygenase
Primary source
dictyBase:DDB_G0278781
Locus tag
DDB_G0278781
See related
AmoebaDB:DDB_G0278781; VEuPathDB:DDB_G0278781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0206188; DDBDRAFT_0231664; DDB_0206188; DDB_0231664
Try the new Gene page
Try the new Transcripts and proteins table
See pah in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_007089.4 (1172682..1174440)

Chromosome 3 - NC_007089.4Genomic Context describing neighboring genes Neighboring gene GDT family protein kinase Neighboring gene aconitase, mitochondrial Neighboring gene hypothetical protein Neighboring gene RNA polymerase II elongator complex subunit

Genomic Sequence:
NC_007089.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dictyostelium phenylalanine hydroxylase is activated by its substrate phenylalanine. Kim HL, et al. FEBS Lett, 2012 Oct 19. PMID 23017206
  2. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Siltberg-Liberles J, et al. Gene, 2008 Dec 31. PMID 18835579
  3. The genome of the social amoeba Dictyostelium discoideum. Eichinger L, et al. Nature, 2005 May 5. PMID 15875012, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DictyoPAH is devoid of the characteristic regulatory mechanisms of mammalian PAH.
    Title: The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine 4-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phenylalanine 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables prephenate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables tetrahydrobiopterin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-phenylalanine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-tyrosine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within asexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Preferred Names
phenylalanine 4-monooxygenase
Names
phenylalanine hydroxylase

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007089.4 Reference assembly

    Range
    1172682..1174440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_636867.1 → XP_641959.1  phenylalanine 4-monooxygenase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_641959.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q54XS1
    Conserved Domains (3) summary
    TIGR01268
    Location:20 → 440
    Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    cd04880
    Location:20 → 91
    ACT_AAAH-PDT-like; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
    pfam00351
    Location:107 → 437
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous