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NPFF neuropeptide FF-amide peptide precursor [ Homo sapiens (human) ]

Gene ID: 8620, updated on 2-Mar-2021

Summary

Official Symbol
NPFFprovided by HGNC
Official Full Name
neuropeptide FF-amide peptide precursorprovided by HGNC
Primary source
HGNC:HGNC:7901
See related
Ensembl:ENSG00000139574 MIM:604643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMRFAL
Summary
This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in skin (RPKM 3.8), spleen (RPKM 2.1) and 24 other tissues See more
Orthologs
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Genomic context

See NPFF in Genome Data Viewer
Location:
12q13.13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53506688..53507484, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53900472..53901268, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene Sharpr-MPRA regulatory region 3466 Neighboring gene ATF7-NPFF readthrough Neighboring gene uncharacterized LOC100652999 Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene activating transcription factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of neuropeptide FF-amide peptide precursor (NPFF) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
somatostatin secretion IEA
Inferred from Electronic Annotation
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
vasopressin secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pro-FMRFamide-related neuropeptide FF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320296.2NP_001307225.1  pro-FMRFamide-related neuropeptide FF isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains an intron compared to variant 1. The encoded isoform (2) is longer, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    BC035758, BC104234
    UniProtKB/Swiss-Prot
    O15130
    Conserved Domains (1) summary
    pfam15085
    Location:54116
    NPFF; Neuropeptide FF
  2. NM_003717.4NP_003708.1  pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_003708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AF005271, BC035758
    Consensus CDS
    CCDS8862.1
    UniProtKB/Swiss-Prot
    O15130
    Related
    ENSP00000267017.3, ENST00000267017.3
    Conserved Domains (1) summary
    pfam15085
    Location:51113
    NPFF; Neuropeptide FF

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53506688..53507484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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