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CADPS calcium dependent secretion activator [ Homo sapiens (human) ]

Gene ID: 8618, updated on 22-May-2022

Summary

Official Symbol
CADPSprovided by HGNC
Official Full Name
calcium dependent secretion activatorprovided by HGNC
Primary source
HGNC:HGNC:1426
See related
Ensembl:ENSG00000163618 MIM:604667; AllianceGenome:HGNC:1426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPS; CAPS1; CADPS1; UNC-31
Summary
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Expression
Biased expression in brain (RPKM 14.7), adrenal (RPKM 5.4) and 9 other tissues See more
Orthologs
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Genomic context

See CADPS in Genome Data Viewer
Location:
3p14.2
Exon count:
36
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (62398348..62875416, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (62441892..62919090, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (62384023..62861091, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs435 Neighboring gene uncharacterized LOC105377647 Neighboring gene VISTA enhancer hs1316 Neighboring gene FEZ family zinc finger 2 Neighboring gene Sharpr-MPRA regulatory region 8400 Neighboring gene Sharpr-MPRA regulatory region 14545 Neighboring gene RNA, 7SL, cytoplasmic 863, pseudogene Neighboring gene ribosomal protein L14 pseudogene 2 Neighboring gene RNA, U6 small nuclear 139, pseudogene Neighboring gene ribosomal protein S10 pseudogene 10 Neighboring gene keratin 8 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium-dependent secretion activator 1
Names
CAPS-1
Ca++-dependent secretion activator
Ca2+ dependent secretion activator
Ca2+-dependent activator protein for secretion
Ca2+-regulated cytoskeletal protein
calcium-dependent activator protein for secretion 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047093.1 RefSeqGene

    Range
    4974..482042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003716.4NP_003707.2  calcium-dependent secretion activator 1 isoform 1

    See identical proteins and their annotated locations for NP_003707.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC012519, AC092039, AC104161
    Consensus CDS
    CCDS46858.1
    UniProtKB/Swiss-Prot
    Q9ULU8
    Related
    ENSP00000373215.4, ENST00000383710.9
    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836940
    DUF1041; Domain of Unknown Function (DUF1041)
  2. NM_183393.3NP_899630.1  calcium-dependent secretion activator 1 isoform 3

    See identical proteins and their annotated locations for NP_899630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is the shortest isoform and lacks multiple internal regions, compared to isoform 1.
    Source sequence(s)
    AC012519, AC092039, AC104161
    Consensus CDS
    CCDS2898.1
    UniProtKB/Swiss-Prot
    Q9ULU8
    Related
    ENSP00000350632.3, ENST00000357948.7
    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:819910
    DUF1041; Domain of Unknown Function (DUF1041)
  3. NM_183394.3NP_899631.1  calcium-dependent secretion activator 1 isoform 2

    See identical proteins and their annotated locations for NP_899631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than, and contains internal differences, compared to isoform 1.
    Source sequence(s)
    AC012519, AC092039, AC104161
    Consensus CDS
    CCDS2899.1
    UniProtKB/Swiss-Prot
    Q9ULU8
    Related
    ENSP00000283269.9, ENST00000283269.13
    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836950
    DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    62398348..62875416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534200.4XP_011532502.1  calcium-dependent secretion activator 1 isoform X45

    See identical proteins and their annotated locations for XP_011532502.1

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836927
    DUF1041; Domain of Unknown Function (DUF1041)
  2. XM_011534199.3XP_011532501.1  calcium-dependent secretion activator 1 isoform X43

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:836927
    DUF1041; Domain of Unknown Function (DUF1041)
  3. XM_017007378.2XP_016862867.1  calcium-dependent secretion activator 1 isoform X35

  4. XM_011534198.4XP_011532500.1  calcium-dependent secretion activator 1 isoform X42

    See identical proteins and their annotated locations for XP_011532500.1

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836933
    DUF1041; Domain of Unknown Function (DUF1041)
  5. XM_017007377.3XP_016862866.1  calcium-dependent secretion activator 1 isoform X34

  6. XM_011534191.4XP_011532493.1  calcium-dependent secretion activator 1 isoform X24

    See identical proteins and their annotated locations for XP_011532493.1

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836950
    DUF1041; Domain of Unknown Function (DUF1041)
  7. XM_017007368.2XP_016862857.1  calcium-dependent secretion activator 1 isoform X23

  8. XM_047449109.1XP_047305065.1  calcium-dependent secretion activator 1 isoform X47

  9. XM_047449107.1XP_047305063.1  calcium-dependent secretion activator 1 isoform X38

  10. XM_047449103.1XP_047305059.1  calcium-dependent secretion activator 1 isoform X22

  11. XM_011534197.3XP_011532499.1  calcium-dependent secretion activator 1 isoform X36

    See identical proteins and their annotated locations for XP_011532499.1

    UniProtKB/TrEMBL
    F1T0E5
    Related
    ENSP00000484365.1, ENST00000612439.4
    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:889980
    DUF1041; Domain of Unknown Function (DUF1041)
  12. XM_047449105.1XP_047305061.1  calcium-dependent secretion activator 1 isoform X32

  13. XM_006713378.4XP_006713441.2  calcium-dependent secretion activator 1 isoform X44

    See identical proteins and their annotated locations for XP_006713441.2

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840931
    DUF1041; Domain of Unknown Function (DUF1041)
  14. XM_047449108.1XP_047305064.1  calcium-dependent secretion activator 1 isoform X41

  15. XM_011534203.3XP_011532505.1  calcium-dependent secretion activator 1 isoform X48

    See identical proteins and their annotated locations for XP_011532505.1

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840934
    DUF1041; Domain of Unknown Function (DUF1041)
  16. XM_011534196.3XP_011532498.1  calcium-dependent secretion activator 1 isoform X30

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:840934
    DUF1041; Domain of Unknown Function (DUF1041)
  17. XM_017007386.3XP_016862875.1  calcium-dependent secretion activator 1 isoform X40

  18. XM_017007374.3XP_016862863.1  calcium-dependent secretion activator 1 isoform X31

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840937
    DUF1041; Domain of Unknown Function (DUF1041)
  19. XM_011534194.3XP_011532496.1  calcium-dependent secretion activator 1 isoform X27

    See identical proteins and their annotated locations for XP_011532496.1

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840944
    DUF1041; Domain of Unknown Function (DUF1041)
  20. XM_011534193.3XP_011532495.1  calcium-dependent secretion activator 1 isoform X26

    Conserved Domains (1) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
  21. XM_017007383.3XP_016862872.1  calcium-dependent secretion activator 1 isoform X39

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:840954
    DUF1041; Domain of Unknown Function (DUF1041)
  22. XM_047449106.1XP_047305062.1  calcium-dependent secretion activator 1 isoform X37

  23. XM_047449102.1XP_047305058.1  calcium-dependent secretion activator 1 isoform X20

  24. XM_017007376.3XP_016862865.1  calcium-dependent secretion activator 1 isoform X33

  25. XM_011534195.3XP_011532497.1  calcium-dependent secretion activator 1 isoform X29

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:893984
    DUF1041; Domain of Unknown Function (DUF1041)
  26. XM_011534183.3XP_011532485.1  calcium-dependent secretion activator 1 isoform X14

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:893984
    DUF1041; Domain of Unknown Function (DUF1041)
  27. XM_047449099.1XP_047305055.1  calcium-dependent secretion activator 1 isoform X11

  28. XM_017007371.3XP_016862860.1  calcium-dependent secretion activator 1 isoform X28

  29. XM_017007363.3XP_016862852.1  calcium-dependent secretion activator 1 isoform X13

  30. XM_011534182.3XP_011532484.1  calcium-dependent secretion activator 1 isoform X12

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:893990
    DUF1041; Domain of Unknown Function (DUF1041)
  31. XM_011534180.3XP_011532482.1  calcium-dependent secretion activator 1 isoform X10

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:893997
    DUF1041; Domain of Unknown Function (DUF1041)
  32. XM_011534192.3XP_011532494.1  calcium-dependent secretion activator 1 isoform X25

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:893993
    DUF1041; Domain of Unknown Function (DUF1041)
  33. XM_047449098.1XP_047305054.1  calcium-dependent secretion activator 1 isoform X9

  34. XM_017007366.3XP_016862855.1  calcium-dependent secretion activator 1 isoform X21

    Conserved Domains (1) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
  35. XM_011534189.3XP_011532491.1  calcium-dependent secretion activator 1 isoform X18

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:8931007
    DUF1041; Domain of Unknown Function (DUF1041)
  36. XM_047449097.1XP_047305053.1  calcium-dependent secretion activator 1 isoform X8

  37. XM_011534178.3XP_011532480.1  calcium-dependent secretion activator 1 isoform X7

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:8931007
    DUF1041; Domain of Unknown Function (DUF1041)
  38. XM_047449094.1XP_047305050.1  calcium-dependent secretion activator 1 isoform X2

  39. XM_047449101.1XP_047305057.1  calcium-dependent secretion activator 1 isoform X19

  40. XM_047449100.1XP_047305056.1  calcium-dependent secretion activator 1 isoform X16

  41. XM_047449096.1XP_047305052.1  calcium-dependent secretion activator 1 isoform X5

  42. XM_047449095.1XP_047305051.1  calcium-dependent secretion activator 1 isoform X4

  43. XM_047449093.1XP_047305049.1  calcium-dependent secretion activator 1 isoform X1

  44. XM_017007364.3XP_016862853.1  calcium-dependent secretion activator 1 isoform X17

  45. XM_024453799.2XP_024309567.1  calcium-dependent secretion activator 1 isoform X15

    Conserved Domains (2) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:8931013
    DUF1041; Domain of Unknown Function (DUF1041)
  46. XM_017007360.3XP_016862849.1  calcium-dependent secretion activator 1 isoform X6

  47. XM_011534177.3XP_011532479.1  calcium-dependent secretion activator 1 isoform X3

    Conserved Domains (4) summary
    smart00239
    Location:399482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:8931013
    DUF1041; Domain of Unknown Function (DUF1041)
  48. XM_011534202.4XP_011532504.1  calcium-dependent secretion activator 1 isoform X46

    Conserved Domains (3) summary
    cd01234
    Location:515634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523622
    PH; PH domain
    pfam06292
    Location:893918
    DUF1041; Domain of Unknown Function (DUF1041)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    62441892..62919090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)