Format

Send to:

Choose Destination

PLPP3 phospholipid phosphatase 3 [ Homo sapiens (human) ]

Gene ID: 8613, updated on 24-Nov-2020

Summary

Official Symbol
PLPP3provided by HGNC
Official Full Name
phospholipid phosphatase 3provided by HGNC
Primary source
HGNC:HGNC:9229
See related
Ensembl:ENSG00000162407 MIM:607125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPP3; VCIP; Dri42; PAP2B; PPAP2B
Summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
Expression
Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues See more
Orthologs

Genomic context

See PLPP3 in Genome Data Viewer
Location:
1p32.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (56494761..56579563, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (56960419..57045257, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6809 Neighboring gene Sharpr-MPRA regulatory region 2463 Neighboring gene ribosomal protein L21 pseudogene 23 Neighboring gene ribosomal protein L23a pseudogene 85 Neighboring gene uncharacterized LOC101929935 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.
GeneReviews: Not available
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
GeneReviews: Not available
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
GeneReviews: Not available
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
GeneReviews: Not available
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
GeneReviews: Not available
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ceramide-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingosine-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of sphingolipid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
sphingosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
adherens junction TAS
Traceable Author Statement
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phospholipid phosphatase 3
Names
PAP2 beta
lipid phosphate phosphohydrolase 3
phosphatidate phosphohydrolase type 2b
phosphatidic acid phosphatase type 2B
type-2 phosphatidic acid phosphatase-beta
vascular endothelial growth factor and type I collagen inducible
NP_003704.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003713.5NP_003704.3  phospholipid phosphatase 3

    See identical proteins and their annotated locations for NP_003704.3

    Status: REVIEWED

    Source sequence(s)
    AC099562, AF043329, BQ027458, DA580891
    Consensus CDS
    CCDS604.1
    UniProtKB/Swiss-Prot
    O14495
    Related
    ENSP00000360296.3, ENST00000371250.4
    Conserved Domains (1) summary
    cd03384
    Location:125271
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    56494761..56579563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177414.1: Suppressed sequence

    Description
    NM_177414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns to the reference assembly with non-consensus splice sites for the intron in the 5' UTR.
Support Center