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PLPP2 phospholipid phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 8612, updated on 21-Dec-2019

Summary

Official Symbol
PLPP2provided by HGNC
Official Full Name
phospholipid phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:9230
See related
Ensembl:ENSG00000141934 MIM:607126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPP2; PAP-2c; PAP2-g; PPAP2C
Summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues See more
Orthologs

Genomic context

See PLPP2 in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (281043..291413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (281040..291435, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928344 Neighboring gene uncharacterized LOC107985295 Neighboring gene PLPP2 intron CAGE-defined low expression enhancer Neighboring gene vomeronasal 2 receptor 11 pseudogene Neighboring gene MIER family member 2 Neighboring gene theg spermatid protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phospholipid phosphatase 2
Names
PAP2-gamma
PAP2c
lipid phosphate phosphohydrolase 2
phosphatidate phosphohydrolase type 2c
phosphatidic acid phosphatase 2c
phosphatidic acid phosphatase type 2C
phosphatidic acid phosphohydrolase type 2c
type-2 phosphatidic acid phosphatase-gamma
NP_003703.1
NP_803545.1
NP_808211.1
XP_011526698.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003712.4NP_003703.1  phospholipid phosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_003703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' region, including the 5' UTR and 5' coding region, as compared to variant 3. The resulting isoform (1) has a distinct and shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AA428937, AF047760, BM050291, BM982485
    Consensus CDS
    CCDS12023.1
    UniProtKB/Swiss-Prot
    O43688
    Related
    ENSP00000388565.2, ENST00000434325.7
    Conserved Domains (1) summary
    cd03384
    Location:94240
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_177526.3NP_803545.1  phospholipid phosphatase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon, which results in a downstream translation start codon, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AA428937, BC002806, BM050291, BM982485, HY160303
    Consensus CDS
    CCDS45889.1
    UniProtKB/Swiss-Prot
    O43688
    Related
    ENSP00000269812.2, ENST00000269812.7
    Conserved Domains (1) summary
    cd03384
    Location:38184
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  3. NM_177543.3NP_808211.1  phospholipid phosphatase 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AA428937, AF047760, BE615792, BG831889, BM982485
    Consensus CDS
    CCDS12024.1
    UniProtKB/Swiss-Prot
    O43688
    Related
    ENSP00000329697.1, ENST00000327790.7
    Conserved Domains (1) summary
    cd03384
    Location:115261
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    281043..291413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528396.2XP_011526698.1  phospholipid phosphatase 2 isoform X1

    Conserved Domains (1) summary
    cd03384
    Location:100246
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
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