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KLF7 KLF transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 8609, updated on 17-Jun-2024

Summary

Official Symbol
KLF7provided by HGNC
Official Full Name
KLF transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:6350
See related
Ensembl:ENSG00000118263 MIM:604865; AllianceGenome:HGNC:6350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UKLF
Summary
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

See KLF7 in Genome Data Viewer
Location:
2q33.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207074137..207173851, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (207556313..207657581, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207938861..208031970, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 2 Neighboring gene microRNA 3130-1 Neighboring gene microRNA 3130-2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207671457-207672284 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676275-207676890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676891-207677508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12270 Neighboring gene carboxypeptidase O Neighboring gene Sharpr-MPRA regulatory region 8398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207901421-207902246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207902247-207903074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17029 Neighboring gene Sharpr-MPRA regulatory region 11101 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208007006-208007507 Neighboring gene microRNA 2355 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208013849-208014350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12271 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028265-208028973 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028974-208029682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17030 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:208030391-208031099 and GRCh37_chr2:208031100-208031807 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208031808-208032516 Neighboring gene MYOSLID antisense RNA 1 Neighboring gene microRNA 7845 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208064814-208065392 Neighboring gene MPRA-validated peak4025 silencer Neighboring gene uncharacterized LOC124907971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17032 Neighboring gene myocardin-induced smooth muscle lncRNA, inducer of differentiation

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 7
Names
Kruppel like factor 7
Kruppel-like factor 7 (ubiquitous)
ubiquitous Kruppel-like factor
ubiquitous Kruppel-like transcription factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052989.2 RefSeqGene

    Range
    12903..104714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270942.1NP_001257871.1  Krueppel-like factor 7 isoform 2

    See identical proteins and their annotated locations for NP_001257871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC008062, BC012919, DA800775
    Consensus CDS
    CCDS59439.1
    UniProtKB/Swiss-Prot
    O75840
    Related
    ENSP00000398572.1, ENST00000423015.5
  2. NM_001270943.2NP_001257872.1  Krueppel-like factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001257872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007879, AC008062
    Consensus CDS
    CCDS59440.1
    UniProtKB/TrEMBL
    Q4ZG79
    Related
    ENSP00000387510.1, ENST00000421199.5
    Conserved Domains (3) summary
    COG5048
    Location:179251
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:246268
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_001270944.2NP_001257873.1  Krueppel-like factor 7 isoform 4

    See identical proteins and their annotated locations for NP_001257873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007879, AC008062
    Consensus CDS
    CCDS59438.1
    UniProtKB/TrEMBL
    Q4ZG79
    Related
    ENSP00000413590.2, ENST00000435602.2
    Conserved Domains (3) summary
    COG5048
    Location:184256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251273
    zf-C2H2; Zinc finger, C2H2 type
  4. NM_003709.4NP_003700.1  Krueppel-like factor 7 isoform 1

    See identical proteins and their annotated locations for NP_003700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007879, AC008062
    Consensus CDS
    CCDS2373.1
    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
    Related
    ENSP00000309570.6, ENST00000309446.11
    Conserved Domains (5) summary
    COG5048
    Location:212284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265290
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2220
    KLF7_N; N-terminal domain of Kruppel-like factor 7

RNA

  1. NR_073108.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008062, DA023826

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    207074137..207173851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446149.1XP_047302105.1  Krueppel-like factor 7 isoform X3

    UniProtKB/TrEMBL
    Q4ZG79
  2. XM_047446146.1XP_047302102.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  3. XM_047446145.1XP_047302101.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  4. XM_047446147.1XP_047302103.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  5. XM_047446144.1XP_047302100.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  6. XM_017005161.2XP_016860650.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
    Conserved Domains (5) summary
    COG5048
    Location:212284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265290
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2220
    KLF7_N; N-terminal domain of Kruppel-like factor 7
  7. XM_017005164.3XP_016860653.1  Krueppel-like factor 7 isoform X5

    UniProtKB/Swiss-Prot
    O75840
    Related
    ENSP00000515454.1, ENST00000703734.1
  8. XM_047446148.1XP_047302104.1  Krueppel-like factor 7 isoform X2

    UniProtKB/TrEMBL
    Q4ZG79
  9. XM_011512075.3XP_011510377.1  Krueppel-like factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A994J6Y4
    Conserved Domains (2) summary
    sd00017
    Location:221243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:219243
    zf-C2H2; Zinc finger, C2H2 type
  10. XM_047446150.1XP_047302106.1  Krueppel-like factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A994J6Y4

RNA

  1. XR_923051.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    207556313..207657581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344310.1XP_054200285.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  2. XM_054344311.1XP_054200286.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  3. XM_054344313.1XP_054200288.1  Krueppel-like factor 7 isoform X3

    UniProtKB/TrEMBL
    Q4ZG79
  4. XM_054344309.1XP_054200284.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  5. XM_054344308.1XP_054200283.1  Krueppel-like factor 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
    UniProtKB/TrEMBL
    B3KNE6
  6. XM_054344316.1XP_054200291.1  Krueppel-like factor 7 isoform X5

  7. XM_054344312.1XP_054200287.1  Krueppel-like factor 7 isoform X2

    UniProtKB/TrEMBL
    Q4ZG79
  8. XM_054344314.1XP_054200289.1  Krueppel-like factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A994J6Y4
  9. XM_054344315.1XP_054200290.1  Krueppel-like factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A994J6Y4

RNA

  1. XR_008486574.1 RNA Sequence

  2. XR_008486573.1 RNA Sequence