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KLF7 Kruppel like factor 7 [ Homo sapiens (human) ]

Gene ID: 8609, updated on 12-Oct-2019

Summary

Official Symbol
KLF7provided by HGNC
Official Full Name
Kruppel like factor 7provided by HGNC
Primary source
HGNC:HGNC:6350
See related
Ensembl:ENSG00000118263 MIM:604865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UKLF
Summary
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues See more
Orthologs

Genomic context

See KLF7 in Genome Data Viewer
Location:
2q33.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (207074137..207173851, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207938861..208031970, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 2 Neighboring gene microRNA 3130-1 Neighboring gene microRNA 3130-2 Neighboring gene carboxypeptidase O Neighboring gene microRNA 2355 Neighboring gene MYOSLID antisense RNA 1 Neighboring gene microRNA 7845 Neighboring gene myocardin-induced smooth muscle lncRNA, inducer of differentiation Neighboring gene long intergenic non-protein coding RNA 1802 Neighboring gene microRNA 1302-4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 7
Names
Kruppel-like factor 7 (ubiquitous)
ubiquitous Kruppel-like factor
ubiquitous Kruppel-like transcription factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052989.1 RefSeqGene

    Range
    6231..98110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270942.1NP_001257871.1  Krueppel-like factor 7 isoform 2

    See identical proteins and their annotated locations for NP_001257871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC008062, BC012919, DA800775
    Consensus CDS
    CCDS59439.1
    UniProtKB/Swiss-Prot
    O75840
    Related
    ENSP00000398572.1, ENST00000423015.5
  2. NM_001270943.2NP_001257872.1  Krueppel-like factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001257872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007879, AC008062
    Consensus CDS
    CCDS59440.1
    UniProtKB/Swiss-Prot
    O75840
    Related
    ENSP00000387510.1, ENST00000421199.5
    Conserved Domains (3) summary
    COG5048
    Location:179251
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:246268
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_001270944.1NP_001257873.1  Krueppel-like factor 7 isoform 4

    See identical proteins and their annotated locations for NP_001257873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC008062, AK297312, DC370575
    Consensus CDS
    CCDS59438.1
    UniProtKB/Swiss-Prot
    O75840
    Related
    ENSP00000403284.2, ENST00000412414.6
    Conserved Domains (3) summary
    COG5048
    Location:184256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251273
    zf-C2H2; Zinc finger, C2H2 type
  4. NM_003709.4NP_003700.1  Krueppel-like factor 7 isoform 1

    See identical proteins and their annotated locations for NP_003700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007879, AC008062
    Consensus CDS
    CCDS2373.1
    UniProtKB/Swiss-Prot
    O75840
    UniProtKB/TrEMBL
    A0A024R3X8
    Related
    ENSP00000309570.6, ENST00000309446.11
    Conserved Domains (3) summary
    COG5048
    Location:212284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279301
    zf-C2H2; Zinc finger, C2H2 type

RNA

  1. NR_073108.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007879, AC008062, DA023826

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    207074137..207173851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512074.2XP_011510376.1  Krueppel-like factor 7 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:191249
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233258
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024453196.1XP_024308964.1  Krueppel-like factor 7 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:191249
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233258
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011512072.2XP_011510374.1  Krueppel-like factor 7 isoform X1

    See identical proteins and their annotated locations for XP_011510374.1

    Conserved Domains (3) summary
    COG5048
    Location:224282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266291
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006712815.3XP_006712878.1  Krueppel-like factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006712878.1

    Conserved Domains (3) summary
    COG5048
    Location:224282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266291
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017005161.1XP_016860650.1  Krueppel-like factor 7 isoform X2

    UniProtKB/Swiss-Prot
    O75840
    UniProtKB/TrEMBL
    A0A024R3X8
    Conserved Domains (3) summary
    COG5048
    Location:212284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279301
    zf-C2H2; Zinc finger, C2H2 type
  6. XM_005246926.3XP_005246983.1  Krueppel-like factor 7 isoform X1

    See identical proteins and their annotated locations for XP_005246983.1

    Conserved Domains (3) summary
    COG5048
    Location:224282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266291
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011512073.2XP_011510375.1  Krueppel-like factor 7 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:193251
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193212
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:235260
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017005164.2XP_016860653.1  Krueppel-like factor 7 isoform X7

    UniProtKB/Swiss-Prot
    O75840
  9. XM_017005162.1XP_016860651.1  Krueppel-like factor 7 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:196254
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:238263
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011512075.2XP_011510377.1  Krueppel-like factor 7 isoform X6

    Conserved Domains (2) summary
    sd00017
    Location:221243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:219243
    zf-C2H2; Zinc finger, C2H2 type
  11. XM_017005163.2XP_016860652.1  Krueppel-like factor 7 isoform X6

    Conserved Domains (2) summary
    sd00017
    Location:221243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:219243
    zf-C2H2; Zinc finger, C2H2 type

RNA

  1. XR_923051.2 RNA Sequence

  2. XR_001739009.2 RNA Sequence

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