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RDH16 retinol dehydrogenase 16 [ Homo sapiens (human) ]

Gene ID: 8608, updated on 29-Mar-2018

Summary

Official Symbol
RDH16provided by HGNC
Official Full Name
retinol dehydrogenase 16provided by HGNC
Primary source
HGNC:HGNC:29674
See related
Ensembl:ENSG00000139547 Vega:OTTHUMG00000170895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RODH-4; SDR9C8
Expression
Restricted expression toward liver (RPKM 111.9) See more
Orthologs

Genomic context

See RDH16 in Genome Data Viewer
Location:
12q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (56951431..56959374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57345215..57353158, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 9C member 7 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene origin of replication ori6 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene G protein-coupled receptor 182

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinol dehydrogenase 16
Names
microsomal NAD+-dependent retinol dehydrogenase 4
retinol dehydrogenase 16 (all-trans and 13-cis)
retinol dehydrogenase 16 (all-trans)
short chain dehydrogenase/reductase family 9C, member 8
sterol/retinol dehydrogenase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320108.1NP_001307037.1  retinol dehydrogenase 16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and initiates translation at an alternate downstream start codon compared to variant 1. The encoded isoform (2) has a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB209332, AW449664
    UniProtKB/TrEMBL
    Q59FX7
    Conserved Domains (1) summary
    cl21454
    Location:46160
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_003708.4NP_003699.3  retinol dehydrogenase 16 isoform 1

    See identical proteins and their annotated locations for NP_003699.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB209332, AC026120, AF057034, AW449664
    Consensus CDS
    CCDS41797.1
    UniProtKB/Swiss-Prot
    O75452
    UniProtKB/TrEMBL
    Q59FX7
    Related
    ENSP00000381206.3, OTTHUMP00000244666, ENST00000398138.4, OTTHUMT00000410898
    Conserved Domains (2) summary
    pfam00106
    Location:30218
    adh_short; short chain dehydrogenase
    cl21454
    Location:30305
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    56951431..56959374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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