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RDH16 retinol dehydrogenase 16 [ Homo sapiens (human) ]

Gene ID: 8608, updated on 17-Sep-2024

Summary

Official Symbol
RDH16provided by HGNC
Official Full Name
retinol dehydrogenase 16provided by HGNC
Primary source
HGNC:HGNC:29674
See related
Ensembl:ENSG00000139547 MIM:620043; AllianceGenome:HGNC:29674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RODH4; RODH-4; SDR9C8; hRDH-E
Summary
Enables NAD-retinol dehydrogenase activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. Involved in steroid metabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver (RPKM 111.9) See more
Orthologs
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Genomic context

See RDH16 in Genome Data Viewer
Location:
12q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56951431..56957608, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56919300..56925477, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57345215..57351392, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 9C member 7 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene origin of replication ori6 Neighboring gene uncharacterized LOC124902945 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.2240 Neighboring gene G protein-coupled receptor 182 Neighboring gene zinc finger and BTB domain containing 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinol dehydrogenase 16
Names
human epidermal retinol dehydrogenase
microsomal NAD+-dependent retinol dehydrogenase 4
retinol dehydrogenase 16 (all-trans and 13-cis)
retinol dehydrogenase 16 (all-trans)
short chain dehydrogenase/reductase family 9C, member 8
sterol/retinol dehydrogenase
NP_001307037.1
NP_003699.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320108.2NP_001307037.1  retinol dehydrogenase 16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and initiates translation at an alternate downstream start codon compared to variant 1. The encoded isoform (2) has a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB209332, AW449664
    UniProtKB/TrEMBL
    Q59FX7
    Conserved Domains (1) summary
    cl21454
    Location:46160
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_003708.5NP_003699.3  retinol dehydrogenase 16 isoform 1

    See identical proteins and their annotated locations for NP_003699.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB209332, AC026120, AF057034, AW449664
    Consensus CDS
    CCDS41797.1
    UniProtKB/Swiss-Prot
    O75452, Q9UNV2
    Related
    ENSP00000381206.3, ENST00000398138.5
    Conserved Domains (2) summary
    pfam00106
    Location:30218
    adh_short; short chain dehydrogenase
    cl21454
    Location:30305
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56951431..56957608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56919300..56925477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)