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NOP14 NOP14 nucleolar protein [ Homo sapiens (human) ]

Gene ID: 8602, updated on 24-Nov-2020

Summary

Official Symbol
NOP14provided by HGNC
Official Full Name
NOP14 nucleolar proteinprovided by HGNC
Primary source
HGNC:HGNC:16821
See related
Ensembl:ENSG00000087269 MIM:611526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UTP2; NOL14; C4orf9; RES425; RES4-25
Summary
This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in lymph node (RPKM 10.9), appendix (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See NOP14 in Genome Data Viewer
Location:
4p16.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (2937936..2963506, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2939663..2965233, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene adducin 1 Neighboring gene NOP14 antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene RNA, U6 small nuclear 204, pseudogene Neighboring gene HTT antisense RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
 
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
 
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
 
maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
90S preribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
Noc4p-Nop14p complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Noc4p-Nop14p complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nucleolar protein 14
Names
NOP14 nucleolar protein homolog
probable nucleolar complex protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291978.2NP_001278907.1  nucleolar protein 14 isoform 1

    See identical proteins and their annotated locations for NP_001278907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025692, AK292939
    Consensus CDS
    CCDS33945.1
    UniProtKB/Swiss-Prot
    P78316
    UniProtKB/TrEMBL
    A8KA74
    Related
    ENSP00000405068.2, ENST00000416614.7
    Conserved Domains (2) summary
    pfam04147
    Location:20846
    Nop14; Nop14-like family
    cl03951
    Location:202321
    CDC37_N; Cdc37 N terminal kinase binding
  2. NM_001291979.2NP_001278908.1  nucleolar protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001278908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 3' coding region and differs in the 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK025692, AK292939, BC026035
    Consensus CDS
    CCDS77893.1
    UniProtKB/Swiss-Prot
    P78316
    UniProtKB/TrEMBL
    A8KA74
    Related
    ENSP00000381146.4, ENST00000398071.4
    Conserved Domains (2) summary
    pfam04147
    Location:20776
    Nop14; Nop14-like family
    cl03951
    Location:202321
    CDC37_N; Cdc37 N terminal kinase binding
  3. NM_003703.3NP_003694.1  nucleolar protein 14 isoform 1

    See identical proteins and their annotated locations for NP_003694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF040965, AK025692, AK292939
    Consensus CDS
    CCDS33945.1
    UniProtKB/Swiss-Prot
    P78316
    UniProtKB/TrEMBL
    A8KA74
    Related
    ENSP00000315674.6, ENST00000314262.10
    Conserved Domains (2) summary
    pfam04147
    Location:20846
    Nop14; Nop14-like family
    cl03951
    Location:202321
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    2937936..2963506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_241655.2 RNA Sequence

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