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LY6D lymphocyte antigen 6 family member D [ Homo sapiens (human) ]

Gene ID: 8581, updated on 3-May-2025
Official Symbol
LY6Dprovided by HGNC
Official Full Name
lymphocyte antigen 6 family member Dprovided by HGNC
Primary source
HGNC:HGNC:13348
See related
Ensembl:ENSG00000167656 MIM:606204; AllianceGenome:HGNC:13348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E48; Ly-6D
Summary
Predicted to be involved in lymphocyte differentiation. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in esophagus (RPKM 212.7) and skin (RPKM 206.5) See more
Orthologs
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See LY6D in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142784882..142786539, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143928320..143929977, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143866298..143867955, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902033 Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene secreted LY6/PLAUR domain containing 2 Neighboring gene Ly6/neurotoxin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19608 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:143896321-143897520 Neighboring gene glycosylphosphatidylinositol anchored molecule like Neighboring gene zinc finger HIT-type containing 1 pseudogene 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of lymphocyte antigen 6 complex, locus D (LY6D) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in lymphocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lymphocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
lymphocyte antigen 6D
Names
e48 antigen
lymphocyte antigen 6 complex, locus D

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003695.3NP_003686.1  lymphocyte antigen 6D precursor

    See identical proteins and their annotated locations for NP_003686.1

    Status: VALIDATED

    Source sequence(s)
    BC022806, BC031330, BU689475
    Consensus CDS
    CCDS6390.1
    UniProtKB/Swiss-Prot
    B2R5F1, D3DWJ0, O43783, Q14210, Q6GTV9, Q8TBD4, Q92933
    Related
    ENSP00000301263.4, ENST00000301263.5
    Conserved Domains (1) summary
    smart00134
    Location:2199
    LU; Ly-6 antigen / uPA receptor -like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142784882..142786539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143928320..143929977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)