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LY6D lymphocyte antigen 6 family member D [ Homo sapiens (human) ]

Gene ID: 8581, updated on 7-Jun-2020

Summary

Official Symbol
LY6Dprovided by HGNC
Official Full Name
lymphocyte antigen 6 family member Dprovided by HGNC
Primary source
HGNC:HGNC:13348
See related
Ensembl:ENSG00000167656 MIM:606204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E48; Ly-6D
Expression
Biased expression in esophagus (RPKM 212.7) and skin (RPKM 206.5) See more
Orthologs

Genomic context

See LY6D in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (142784882..142786539, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143866298..143868008, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene secreted LY6/PLAUR domain containing 2 Neighboring gene Ly6/neurotoxin 1 Neighboring gene glycosylphosphatidylinositol anchored molecule like Neighboring gene zinc finger HIT-type containing 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lymphocyte antigen 6 complex, locus D (LY6D) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
lymphocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lymphocyte antigen 6D
Names
e48 antigen
lymphocyte antigen 6 complex, locus D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003695.3NP_003686.1  lymphocyte antigen 6D precursor

    See identical proteins and their annotated locations for NP_003686.1

    Status: VALIDATED

    Source sequence(s)
    BC022806, BC031330, BU689475
    Consensus CDS
    CCDS6390.1
    UniProtKB/Swiss-Prot
    Q14210
    Related
    ENSP00000301263.4, ENST00000301263.5
    Conserved Domains (1) summary
    smart00134
    Location:2199
    LU; Ly-6 antigen / uPA receptor -like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    142784882..142786539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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