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STK16 serine/threonine kinase 16 [ Homo sapiens (human) ]

Gene ID: 8576, updated on 3-Jan-2019

Summary

Official Symbol
STK16provided by HGNC
Official Full Name
serine/threonine kinase 16provided by HGNC
Primary source
HGNC:HGNC:11394
See related
Ensembl:ENSG00000115661 MIM:604719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK; KRCT; MPSK; TSF1; hPSK; PKL12
Expression
Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See STK16 in Genome Data Viewer
Location:
2q35
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (219245455..219250337)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220110192..220115059)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase beta 1 like Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene DnaJ heat shock protein family (Hsp40) member B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39635, MGC16211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to transforming growth factor beta stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 16
Names
TGF-beta-stimulated factor 1
myristoylated and palmitoylated serine/threonine-protein kinase
protein kinase PKL12
protein kinase expressed in day 12 fetal liver
tyrosine-protein kinase STK16
NP_001008910.1
NP_001317142.1
NP_001317143.1
NP_001317144.1
XP_016860649.1
XP_024308963.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008910.3NP_001008910.1  serine/threonine-protein kinase 16 isoform 1

    See identical proteins and their annotated locations for NP_001008910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AF203910, AK292694, BC007381, BP219006, CN268939
    Consensus CDS
    CCDS42822.1
    UniProtKB/Swiss-Prot
    O75716
    UniProtKB/TrEMBL
    A0A024R440
    Related
    ENSP00000386928.3, ENST00000409638.7
    Conserved Domains (1) summary
    cd13986
    Location:19295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  2. NM_001330213.2NP_001317142.1  serine/threonine-protein kinase 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS42822.1
    UniProtKB/Swiss-Prot
    O75716
    UniProtKB/TrEMBL
    A0A024R440
    Related
    ENSP00000379964.2, ENST00000396738.6
    Conserved Domains (1) summary
    cd13986
    Location:19295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  3. NM_001330214.1NP_001317143.1  serine/threonine-protein kinase 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068946, AK298471
    Consensus CDS
    CCDS82573.1
    UniProtKB/TrEMBL
    B4DPS1, B8ZZI5
    Related
    ENSP00000386553.1, ENST00000409743.1
    Conserved Domains (1) summary
    cd13986
    Location:19263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  4. NM_001330215.1NP_001317144.1  serine/threonine-protein kinase 16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068946, AK298471, BP219006
    Consensus CDS
    CCDS86921.1
    UniProtKB/TrEMBL
    B4DPS1
    Related
    ENSP00000386309.3, ENST00000409516.7
    Conserved Domains (1) summary
    cl21453
    Location:29177
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    219245455..219250337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453195.1XP_024308963.1  serine/threonine-protein kinase 16 isoform X1

    Conserved Domains (1) summary
    cd13986
    Location:19263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  2. XM_017005160.2XP_016860649.1  serine/threonine-protein kinase 16 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:11159
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003691.2: Suppressed sequence

    Description
    NM_003691.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_032768.1: Suppressed sequence

    Description
    NM_032768.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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