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STK16 serine/threonine kinase 16 [ Homo sapiens (human) ]

Gene ID: 8576, updated on 12-Aug-2022

Summary

Official Symbol
STK16provided by HGNC
Official Full Name
serine/threonine kinase 16provided by HGNC
Primary source
HGNC:HGNC:11394
See related
Ensembl:ENSG00000115661 MIM:604719; AllianceGenome:HGNC:11394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK; KRCT; MPSK; TSF1; hPSK; PKL12
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See STK16 in Genome Data Viewer
Location:
2q35
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219245479..219250337)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219730246..219735104)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220110201..220115059)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 Neighboring gene galactosidase beta 1 like Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene DnaJ heat shock protein family (Hsp40) member B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39635, MGC16211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 16
Names
TGF-beta-stimulated factor 1
myristoylated and palmitoylated serine/threonine-protein kinase
protein kinase PKL12
protein kinase expressed in day 12 fetal liver
tyrosine-protein kinase STK16
NP_001008910.1
NP_001317142.1
NP_001317143.1
NP_001317144.1
XP_024308963.1
XP_047302096.1
XP_047302097.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008910.4NP_001008910.1  serine/threonine-protein kinase 16 isoform 1

    See identical proteins and their annotated locations for NP_001008910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS42822.1
    UniProtKB/Swiss-Prot
    O75716, Q9UP78
    UniProtKB/TrEMBL
    A0A024R440
    Related
    ENSP00000386928.3, ENST00000409638.7
    Conserved Domains (1) summary
    cd13986
    Location:19295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  2. NM_001330213.2NP_001317142.1  serine/threonine-protein kinase 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS42822.1
    UniProtKB/Swiss-Prot
    O75716, Q9UP78
    UniProtKB/TrEMBL
    A0A024R440
    Related
    ENSP00000379964.2, ENST00000396738.7
    Conserved Domains (1) summary
    cd13986
    Location:19295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  3. NM_001330214.1NP_001317143.1  serine/threonine-protein kinase 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068946, AK298471
    Consensus CDS
    CCDS82573.1
    UniProtKB/TrEMBL
    B4DPS1, B8ZZI5
    Related
    ENSP00000386553.1, ENST00000409743.1
    Conserved Domains (1) summary
    cd13986
    Location:19263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  4. NM_001330215.2NP_001317144.1  serine/threonine-protein kinase 16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS86921.1
    UniProtKB/TrEMBL
    B4DPS1
    Related
    ENSP00000386309.3, ENST00000409516.7
    Conserved Domains (1) summary
    cl21453
    Location:29177
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219245479..219250337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446140.1XP_047302096.1  serine/threonine-protein kinase 16 isoform X1

    UniProtKB/TrEMBL
    B8ZZI5
  2. XM_024453195.2XP_024308963.1  serine/threonine-protein kinase 16 isoform X1

    UniProtKB/TrEMBL
    B8ZZI5
    Conserved Domains (1) summary
    cd13986
    Location:19263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16
  3. XM_047446141.1XP_047302097.1  serine/threonine-protein kinase 16 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219730246..219735104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003691.2: Suppressed sequence

    Description
    NM_003691.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_032768.1: Suppressed sequence

    Description
    NM_032768.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.