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PUG1 Pug1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856934, updated on 7-Jun-2026
Official Symbol
PUG1
Official Full Name
Pug1p
Primary source
SGD:S000000987
Locus tag
YER185W
See related
AllianceGenome:SGD:S000000987; FungiDB:YER185W; VEuPathDB:YER185W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in heme transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See PUG1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (559454..560365)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene 5-formyltetrahydrofolate cyclo-ligase Neighboring gene Tog1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Loop 5 region is important for the activity of the long-chain base transporter Rsb1. Makuta H, et al. J Biochem, 2017 Feb 1. PMID 28175317
  2. Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae. Protchenko O, et al. Eukaryot Cell, 2008 May. PMID 18326586, Free PMC Article
  3. Single-Gene Deletions Contributing to Loss of Heterozygosity in Saccharomyces cerevisiae: Genome-Wide Screens and Reproducibility. Hoffert KM, et al. G3 (Bethesda), 2019 Sep 4. PMID 31270132, Free PMC Article
  4. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Giorgini F, et al. Nat Genet, 2005 May. PMID 15806102, Free PMC Article
  5. Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. Kim H, et al. J Biol Chem, 2003 Mar 21. PMID 12524434

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pug1p induced protoporphyrin IX influx and heme efflux in Saccharomyces cerevisiae.
    Title: Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in heme transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Pug1p
NP_011112.3
  • Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    559454..560365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179075.3 → NP_011112.3  Pug1p

    See identical proteins and their annotated locations for NP_011112.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM94, P40100
    UniProtKB/TrEMBL
    A6ZRE2, B3LRU5, B5VHW6, C7GUZ1, C8Z7L0, G2WD72, N1P583
    Conserved Domains (1) summary
    pfam04479
    Location:84 → 292
    RTA1; RTA1 like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40100.1

Gene LinkOut

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