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RAD3 TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856918, updated on 5-Nov-2017
Gene symbol
RAD3
Gene description
TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3
Primary source
SGD:S000000973
Locus tag
YER171W
Gene type
protein coding
RNA name
TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
REM1
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (527082..529418)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Rph1p Neighboring gene adenylate kinase ADK2 Neighboring gene ATP-dependent RNA helicase BRR2 Neighboring gene Rad24p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent 5'-3' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP-dependent DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to transcription factor activity, core RNA polymerase binding IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair, DNA incision IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation of RNA polymerase II C-terminal domain IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transposition, RNA-mediated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
core TFIIH complex IDA
Inferred from Direct Assay
more info
PubMed 
holo TFIIH complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3
NP_011098.3
  • 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    527082..529418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179061.3NP_011098.3  TPA: TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011098.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06839
    Conserved Domains (1) summary
    TIGR00604
    Location:7717
    rad3; DNA repair helicase (rad3)
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