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DNF1 aminophospholipid-translocating P4-type ATPase DNF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856913, updated on 9-Sep-2018

Summary

Gene symbol
DNF1
Gene description
aminophospholipid-translocating P4-type ATPase DNF1
Primary source
SGD:S000000968
Locus tag
YER166W
Gene type
protein coding
RNA name
aminophospholipid-translocating P4-type ATPase DNF1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See DNF1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (512744..517459)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene chromatin-remodeling ATPase CHD1 Neighboring gene polyadenylate-binding protein Neighboring gene Bck2p Neighboring gene tRNA adenylyltransferase

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid-translocating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid-translocating ATPase activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid-translocating ATPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
phospholipid-translocating ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
ATP hydrolysis coupled ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
endocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular protein transport IGI
Inferred from Genetic Interaction
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation IGI
Inferred from Genetic Interaction
more info
PubMed 
phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
response to pheromone triggering conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell periphery HDA PubMed 
cellular bud neck HDA PubMed 
endoplasmic reticulum HDA PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
mating projection tip membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
phospholipid-translocating ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aminophospholipid-translocating P4-type ATPase DNF1
NP_011093.3
  • Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    512744..517459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179056.3NP_011093.3  TPA: aminophospholipid-translocating P4-type ATPase DNF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011093.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32660
    Conserved Domains (5) summary
    TIGR01652
    Location:1911413
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:776883
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:182240
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:11561406
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:11251156
    HAD_like; Haloacid Dehalogenase-like Hydrolases
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