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RAD4 Rad4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856909, updated on 5-Jan-2025

Summary

Official Symbol
RAD4
Official Full Name
Rad4p
Primary source
SGD:S000000964
Locus tag
YER162C
See related
AllianceGenome:SGD:S000000964; FungiDB:YER162C; VEuPathDB:YER162C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables single-strand break-containing DNA binding activity. Involved in DNA metabolic process; negative regulation of transcription by RNA polymerase II; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Part of nucleotide-excision repair factor 2 complex. Used to study xeroderma pigmentosum. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See RAD4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (500630..502894, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene Spt2p Neighboring gene gamma-glutamylcyclotransferase Neighboring gene chromatin-remodeling ATPase CHD1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables single-strand break-containing DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of XPC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleotide-excision repair factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-excision repair factor 2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Rad4p
NP_011089.4
  • Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2; recognizes and binds damaged DNA with Rad23p during nucleotide excision repair (NER); also involved with Rad23p in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; RAD4 and RAD51 pathways confer resistance to benzo[a]pyrene dihydrodiol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    500630..502894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179052.4NP_011089.4  TPA: Rad4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011089.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM70, P14736
    UniProtKB/TrEMBL
    B5VHT9, N1P562
    Conserved Domains (1) summary
    COG5535
    Location:1669
    RAD4; DNA repair protein RAD4 [DNA replication, recombination, and repair]