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COG3 Golgi transport complex subunit COG3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856901, updated on 23-Jul-2026
Official Symbol
COG3
Official Full Name
Golgi transport complex subunit COG3
Primary source
SGD:S000000959
Locus tag
YER157W
See related
AllianceGenome:SGD:S000000959; FungiDB:YER157W; VEuPathDB:YER157W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GRD20; SEC34
Summary
Enables cargo adaptor activity. Involved in Golgi vesicle transport; cytoplasm to vacuole targeting by the Cvt pathway; and pexophagy. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIbb. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See COG3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (484788..487193)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein BEM2 Neighboring gene Myg1p Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Membrane traffic: exocyst III--makes a family. Short B, et al. Curr Biol, 2002 Jan 8. PMID 11790318
  2. The yeast GRD20 gene is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton. Spelbrink RG, et al. Mol Biol Cell, 1999 Dec. PMID 10588657, Free PMC Article
  3. Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells. Zolov SN, et al. J Cell Biol, 2005 Feb 28. PMID 15728195, Free PMC Article
  4. The Rab GTPase Ypt1p and tethering factors couple protein sorting at the ER to vesicle targeting to the Golgi apparatus. Morsomme P, et al. Dev Cell, 2002 Mar. PMID 11879636
  5. Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery. Suvorova ES, et al. J Biol Chem, 2001 Jun 22. PMID 11292827

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cargo adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cargo adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, vesicle recycling within Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, vesicle recycling within Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, vesicle recycling within Golgi NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of COG complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COG complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of COG complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Golgi transport complex subunit COG3
NP_011084.1
  • Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    484788..487193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179047.1 → NP_011084.1  Golgi transport complex subunit COG3

    See identical proteins and their annotated locations for NP_011084.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM64, P40094
    UniProtKB/TrEMBL
    B3LRS0
    Conserved Domains (1) summary
    pfam04136
    Location:86 → 232
    Sec34; Sec34-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40094.1

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