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PET122 Pet122p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856897, updated on 5-Jul-2025
Official Symbol
PET122
Official Full Name
Pet122p
Primary source
SGD:S000000955
Locus tag
YER153C
See related
AllianceGenome:SGD:S000000955; FungiDB:YER153C; VEuPathDB:YER153C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables translation initiation factor activity. Involved in mitochondrial cytochrome c oxidase assembly and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PET122 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (474041..474805, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene mRNA-binding ubiquitin-specific protease UBP3 Neighboring gene 2-aminoadipate transaminase Neighboring gene membrane insertase OXA1 Neighboring gene GTPase-activating protein BEM2

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of a third nuclear protein-coding gene required specifically for posttranscriptional expression of the mitochondrial COX3 gene is Saccharomyces cerevisiae. Kloeckener-Gruissem B, et al. J Bacteriol, 1988 Mar. PMID 2830240, Free PMC Article
  2. Molecular cloning and nucleotide sequence of the nuclear PET122 gene required for expression of the mitochondrial COX3 gene in S. cerevisiae. Ohmen JD, et al. Nucleic Acids Res, 1988 Nov 25. PMID 2849752, Free PMC Article
  3. Expression of the divergent transcription unit containing the yeast PET122 and OXA1 genes. Marathe SV, et al. Biochem Mol Biol Int, 1999 Jun. PMID 10410243
  4. A genetic link between an mRNA-specific translational activator and the translation system in yeast mitochondria. Haffter P, et al. Genetics, 1990 Jul. PMID 1696234, Free PMC Article
  5. In Saccharomyces cerevisiae, withdrawal of the carbon source results in detachment of glycolytic enzymes from the cytoskeleton and in actin reorganization. Espinoza-Simón E, et al. Fungal Biol, 2020 Jan. PMID 31892373

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Pet122p
NP_011080.1
  • Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    474041..474805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179043.1 → NP_011080.1  TPA: Pet122p

    See identical proteins and their annotated locations for NP_011080.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM60, P10355
    UniProtKB/TrEMBL
    A6ZRB0, B3LRR6, C7GQ43, C8Z7H6, G2WD40, N1P3N3
    Conserved Domains (1) summary
    pfam05476
    Location:6 → 248
    PET122
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10355.2

Gene LinkOut

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