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PEA2 Pea2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856892, updated on 7-Jun-2026
Official Symbol
PEA2
Official Full Name
Pea2p
Primary source
SGD:S000000951
Locus tag
YER149C
See related
AllianceGenome:SGD:S000000951; FungiDB:YER149C; VEuPathDB:YER149C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DFG9; PPF2
Summary
Enables myosin V binding activity. Involved in several processes, including bipolar cellular bud site selection; budding cell apical bud growth; and pseudohyphal growth. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Part of polarisome. Is active in site of polarized growth. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PEA2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (466208..467470, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene cohesin-loading factor complex subunit SCC4 Neighboring gene TATA-binding protein Neighboring gene Spi1p Neighboring gene tRNA-Val

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Saccharomyces cerevisiae MATa mutant cells defective in pointed projection formation in response to alpha-factor at high concentrations. Yorihuzi T, et al. Yeast, 1994 May. PMID 7941743
  2. Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding. Valtz N, et al. J Cell Biol, 1996 Nov. PMID 8909546, Free PMC Article
  3. Modular coherence of protein dynamics in yeast cell polarity system. Gao JT, et al. Proc Natl Acad Sci U S A, 2011 May 3. PMID 21502521, Free PMC Article
  4. Importance of polarisome proteins in reorganization of actin cytoskeleton at low pH in Saccharomyces cerevisiae. Motizuki M, et al. J Biochem, 2009 Nov. PMID 19633059
  5. Actin recovery and bud emergence in osmotically stressed cells requires the conserved actin interacting mitogen-activated protein kinase kinase kinase Ssk2p/MTK1 and the scaffold protein Spa2p. Yuzyuk T, et al. Mol Biol Cell, 2003 Jul. PMID 12857882, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables myosin V binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in budding cell apical bud growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in budding cell apical bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
part_of polarisome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of polarisome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Pea2p
NP_011076.1
  • Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    466208..467470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179039.1 → NP_011076.1  Pea2p

    See identical proteins and their annotated locations for NP_011076.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM56, P40091, Q70DC9, Q70DD1, Q70DD2, Q70DD3, Q70DD4, Q70DD6, Q70DD7, Q70DD8
    UniProtKB/TrEMBL
    A6ZRA6, B3LRR2, C7GQ47, G2WD36, N1PA61
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40091.1

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