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SPT15 TATA-binding protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856891, updated on 29-Jun-2024

Summary

Gene symbol
SPT15
Gene description
TATA-binding protein
Primary source
FungiDB:YER148W
Locus tag
YER148W
See related
SGD:S000000950; AllianceGenome:SGD:S000000950; VEuPathDB:YER148W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BTF1; TBP1
Summary
Enables several functions, including DNA binding activity; RNA polymerase I general transcription initiation factor binding activity; and chromatin binding activity. Involved in transcription, DNA-templated and transposon integration. Located in nucleus. Part of transcription factor TFIID complex and transcription factor TFIIIB complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to several human genes including TBPL2 (TATA-box binding protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SPT15 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (465303..466025)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA-binding protein LSM5 Neighboring gene cohesin-loading factor complex subunit SCC4 Neighboring gene Pea2p Neighboring gene Spi1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIIB complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TATA-binding protein
NP_011075.3
  • TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    465303..466025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179038.3NP_011075.3  TPA: TATA-binding protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011075.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM55, P13393
    UniProtKB/TrEMBL
    A6ZRA5, B3LRR1, B5VHS6, C7GQ48, C8Z7H0, G2WD35, G4XSE0, G4XSG8, G4XSJ4, G4XSK3, N1P3M9
    Conserved Domains (1) summary
    PLN00062
    Location:64239
    PLN00062; TATA-box-binding protein; Provisional