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GLO3 ADP-ribosylation factor GTPase-activating protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856859, updated on 12-Apr-2026
Official Symbol
GLO3
Official Full Name
ADP-ribosylation factor GTPase-activating protein
Primary source
SGD:S000000924
Locus tag
YER122C
See related
AllianceGenome:SGD:S000000924; FungiDB:YER122C; VEuPathDB:YER122C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in COPI coating of Golgi vesicle; endoplasmic reticulum to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in COPI-coated vesicle. Part of COPI vesicle coat. Orthologous to several human genes including ARFGAP2 (ARF GTPase activating protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See GLO3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (402871..404352, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-binding protein SCS2 Neighboring gene uncharacterized protein Neighboring gene casein kinase YCK3 Neighboring gene Dse1p

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An interaction between beta'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
    Title: An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
  2. The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
    Title: The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
  3. demonstrated that glo3Delta cells were defective in the late endosome-to-TGN transport pathway
    Title: The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins.
  4. The ArfGAP Gcs1p accelerates vesicle (v)-target membrane (t)-SNARE complex formation in vitro, indicating that ArfGAPs may act as folding chaperones.
    Title: Interaction of SNAREs with ArfGAPs precedes recruitment of Sec18p/NSF.
  5. The Glo3 and its homologues from other eukaryotes harbor a well-conserved repeated ISSxxxFG sequence near the C-terminus, which is not found in Gcs1p and its homologues.
    Title: The Arf1p GTPase-activating protein Glo3p executes its regulatory function through a conserved repeat motif at its C-terminus.
  6. role in the generation of COPI retrograde transport vesicles
    Title: The ArfGAP Glo3 is required for the generation of COPI vesicles.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPI coating of Golgi vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in COPI coating of Golgi vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COPI vesicle coat IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ADP-ribosylation factor GTPase-activating protein
NP_011048.1
  • ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    402871..404352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179012.1 → NP_011048.1  ADP-ribosylation factor GTPase-activating protein

    See identical proteins and their annotated locations for NP_011048.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM28, P38682
    UniProtKB/TrEMBL
    B3LRN8
    Conserved Domains (1) summary
    COG5347
    Location:9 → 363
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38682.1

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