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GLO3 ADP-ribosylation factor GTPase-activating protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856859, updated on 5-Feb-2023

Summary

Gene symbol
GLO3
Gene description
ADP-ribosylation factor GTPase-activating protein
Primary source
SGD:S000000924
Locus tag
YER122C
See related
AllianceGenome:SGD:S000000924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in COPI coating of Golgi vesicle; endoplasmic reticulum to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in COPI-coated vesicle. Part of COPI vesicle coat. Orthologous to several human genes including ARFGAP2 (ADP ribosylation factor GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See GLO3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (402871..404352, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-binding protein SCS2 Neighboring gene uncharacterized protein Neighboring gene casein kinase YCK3 Neighboring gene Dse1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
part_of COPI vesicle coat IPI
Inferred from Physical Interaction
more info
PubMed 
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADP-ribosylation factor GTPase-activating protein
NP_011048.1
  • ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    402871..404352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179012.1NP_011048.1  TPA: ADP-ribosylation factor GTPase-activating protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011048.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM28, P38682
    UniProtKB/TrEMBL
    A0A8H8ULY6
    Conserved Domains (1) summary
    COG5347
    Location:9363
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]