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SSA4 Hsp70 family chaperone SSA4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856840, updated on 15-May-2020

Summary

Gene symbol
SSA4
Gene description
Hsp70 family chaperone SSA4
Primary source
SGD:S000000905
Locus tag
YER103W
Gene type
protein coding
RNA name
Hsp70 family chaperone SSA4
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YG107

Genomic context

See SSA4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (364589..366517)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ast2p Neighboring gene ribosomal 40S subunit protein S8B Neighboring gene Rtt105p Neighboring gene Nup157p

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SSA4 gene: The SSA4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SRP-dependent cotranslational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding IGI
Inferred from Genetic Interaction
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Hsp70 family chaperone SSA4
NP_011029.3
  • Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    364589..366517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178994.3NP_011029.3  TPA: Hsp70 family chaperone SSA4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011029.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22202
    Conserved Domains (2) summary
    cd10233
    Location:4379
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:4642
    PTZ00009; heat shock 70 kDa protein; Provisional
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