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TSC11 TORC2 complex subunit TSC11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856828, updated on 7-Jun-2026
Official Symbol
TSC11
Official Full Name
TORC2 complex subunit TSC11
Primary source
SGD:S000000895
Locus tag
YER093C
See related
AllianceGenome:SGD:S000000895; FungiDB:YER093C; VEuPathDB:YER093C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AVO3
Summary
Enables protein-membrane adaptor activity. Involved in several processes, including establishment or maintenance of actin cytoskeleton polarity; fungal-type cell wall organization; and protein localization to plasma membrane. Located in cytosol. Part of TORC2 complex. Is active in plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See TSC11 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (343320..347612, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase Neighboring gene Ies5p Neighboring gene Aim11p Neighboring gene proteasome core particle subunit beta 3

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae. Chen PK, et al. Biochem Biophys Res Commun, 2024 Jul 12. PMID 38718572
  2. The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites. Leskoske KL, et al. Genetics, 2017 Sep. PMID 28739659, Free PMC Article
  3. Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes. Kamada Y, et al. J Cell Sci, 2024 Feb 15. PMID 38415789, Free PMC Article
  4. Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress. Muir A, et al. Elife, 2015 Aug 14. PMID 26274562, Free PMC Article
  5. Regulation of ceramide biosynthesis by TOR complex 2. Aronova S, et al. Cell Metab, 2008 Feb. PMID 18249174, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
    Title: Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
  2. Moreover, hyperosmotic conditions block TORC2-dependent Ypk1-mediated Fps1 phosphorylation, causing channel closure, glycerol accumulation, and enhanced survival under hyperosmotic stress.
    Title: Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress.
  3. Avo3p is a structural and signaling scaffold for TORC2.
    Title: Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling.
  4. the function of TSC11 in the regulation of cell integrity
    Title: Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TOR signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell growth IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in plasma membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
TORC2 complex subunit TSC11
NP_011018.1
  • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    343320..347612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178984.1 → NP_011018.1  TORC2 complex subunit TSC11

    See identical proteins and their annotated locations for NP_011018.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM00, P40061
    UniProtKB/TrEMBL
    B3LRL1, C7GRS6
    Conserved Domains (5) summary
    PRK08581
    Location:23 → 323
    PRK08581; amidase domain-containing protein
    pfam14663
    Location:977 → 1080
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:326 → 669
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14666
    Location:853 → 957
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:1147 → 1217
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40061.1

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