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SBH1 Arf family guanine nucleotide exchange factor SBH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856821, updated on 21-Dec-2025
Official Symbol
SBH1
Official Full Name
Arf family guanine nucleotide exchange factor SBH1
Primary source
SGD:S000002128
Locus tag
YER087C-B
See related
AllianceGenome:SGD:S000002128; FungiDB:YER087C-B; VEuPathDB:YER087C-B
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SEB1; YER087C-A
Summary
Enables guanyl-nucleotide exchange factor activity and protein transmembrane transporter activity. Contributes to protein-transporting ATPase activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum membrane. Part of Sec61 translocon complex. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See SBH1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (332582..332830, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene threonine ammonia-lyase ILV1 Neighboring gene putative proline--tRNA ligase AIM10 Neighboring gene Dot6p Neighboring gene type 2C protein phosphatase PTC2

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Inter-species complementation of the translocon beta subunit requires only its transmembrane domain. Leroux A, et al. PLoS One, 2008. PMID 19057642, Free PMC Article
  2. The beta-subunit of the protein-conducting channel of the endoplasmic reticulum functions as the guanine nucleotide exchange factor for the beta-subunit of the signal recognition particle receptor. Helmers J, et al. J Biol Chem, 2003 Jun 27. PMID 12750387
  3. Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation. Barbieri G, et al. J Biol Chem, 2023 Mar. PMID 36639027, Free PMC Article
  4. Protein translocation: is Hsp70 pulling my chain? Jensen RE, et al. Curr Biol, 1999 Oct 21. PMID 10531024
  5. The mammalian and yeast translocon complexes comprise a characteristic Sec61 channel. Erdmann F, et al. Biochem Biophys Res Commun, 2010 Jun 4. PMID 20450886

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sec61 channel subunit Sbh1/Sec61beta promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation.
    Title: Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation.
  2. Data suggest that Bat3 either modulates the Sec61beta/TRC40 pathway in higher eukaryotes or provides an alternative fate for newly synthesised tail-anchored proteins.
    Title: Bat3 promotes the membrane integration of tail-anchored proteins.
  3. Sbh1p co-precipitates with the ER transmembrane protein Rtn1p. Sbh1p-Rtn1p complexes do not appear to contain Sss1p and Sec61p.
    Title: The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.
  4. Ost3p and Ost6p are similar, but do not exist in the same oligosaccharyltransferase complex: Ost3p interacts with Sbh1p, while Ost6p interacts with Sbh2p.
    Title: Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to protein-transporting ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sec61 translocon complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sec61 translocon complex IEA
Inferred from Electronic Annotation
more info
  
part_of Sec61 translocon complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of translocon complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
Arf family guanine nucleotide exchange factor SBH1
NP_011011.3
  • Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    332582..332830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180032.3 → NP_011011.3  TPA: Arf family guanine nucleotide exchange factor SBH1

    See identical proteins and their annotated locations for NP_011011.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLZ4, P52870
    UniProtKB/TrEMBL
    A0A0L8VRM4, A6ZR43, B3LRK5, C7GRS0, C8Z7A2, G2WCX8, N1P582
    Conserved Domains (1) summary
    pfam03911
    Location:38 → 74
    Sec61_beta; Sec61beta family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52870.1

Gene LinkOut

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