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VTC1 Vtc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856803, updated on 18-Sep-2024

Summary

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Official Symbol
VTC1
Official Full Name
Vtc1p
Primary source
SGD:S000000874
Locus tag
YER072W
See related
AllianceGenome:SGD:S000000874; FungiDB:YER072W; VEuPathDB:YER072W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NRF1; PHM4
Summary
Enables mRNA binding activity. Involved in several processes, including lysosomal microautophagy; polyphosphate biosynthetic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum and nuclear membrane. Is intrinsic component of vacuolar membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VTC1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (302806..303195)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribonucleotide-diphosphate reductase subunit RNR1 Neighboring gene Tda2p Neighboring gene aldehyde dehydrogenase (NAD(P)(+)) ALD5 Neighboring gene ribosomal 40S subunit protein S24A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ddi1 is a ubiquitin-dependent protease. Yip MCJ, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32193351, Free PMC Article
  2. The function of Spt3, a subunit of the SAGA complex, in PGK1 transcription is restored only partially when reintroduced by plasmid into taf1 spt3 double mutant yeast strains. Iwami R, et al. Genes Genet Syst, 2020 Aug 27. PMID 32624556
  3. Coupled synthesis and translocation restrains polyphosphate to acidocalcisome-like vacuoles and prevents its toxicity. Gerasimaitė R, et al. J Cell Sci, 2014 Dec 1. PMID 25315834
  4. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, et al. Science, 2009 Apr 24. PMID 19390046
  5. Role of the Vtc proteins in V-ATPase stability and membrane trafficking. Müller O, et al. J Cell Sci, 2003 Mar 15. PMID 12584253

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuolar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar transporter chaperone complex IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar transporter chaperone complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vtc1p
NP_010995.1
  • Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    302806..303195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178963.1 → NP_010995.1  TPA: Vtc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010995.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLX7, P40046
    UniProtKB/TrEMBL
    A6ZR26, B3LRI9, C7GRQ4, C8Z780, G2WCW1, N1P6Z8
    Conserved Domains (1) summary
    COG5264
    Location:1 → 124
    VTC1; Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40046.3

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