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RRP1 ribosomal RNA processing 1 [ Homo sapiens (human) ]

Gene ID: 8568, updated on 3-May-2020

Summary

Official Symbol
RRP1provided by HGNC
Official Full Name
ribosomal RNA processing 1provided by HGNC
Primary source
HGNC:HGNC:18785
See related
Ensembl:ENSG00000160214 MIM:610653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NNP-1; NOP52; RRP1A; D21S2056E
Summary
The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 8.5), testis (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See RRP1 in Genome Data Viewer
Location:
21q22.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (43789551..43805293)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45209418..45223983)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372825 Neighboring gene transmembrane protein 97 pseudogene 1 Neighboring gene apoptosis associated transcript in bladder cancer Neighboring gene myosin light chain 6 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal RNA processing protein 1 homolog A
Names
Nnp1 homolog, nucleolar protein
RRP1-like protein
novel nuclear protein 1
nucleolar protein Nop52
protein NNP-1
ribosomal RNA processing 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046959.1 RefSeqGene

    Range
    5043..20759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003683.6NP_003674.1  ribosomal RNA processing protein 1 homolog A

    See identical proteins and their annotated locations for NP_003674.1

    Status: REVIEWED

    Source sequence(s)
    AI634547, AP001053, BC000380, BI223794, DA275615
    Consensus CDS
    CCDS42951.1
    UniProtKB/Swiss-Prot
    P56182
    Related
    ENSP00000417464.1, ENST00000497547.2
    Conserved Domains (1) summary
    pfam05997
    Location:11219
    Nop52; Nucleolar protein,Nop52

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    43789551..43805293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028486.1XP_016883975.1  ribosomal RNA processing protein 1 homolog A isoform X2

  2. XM_024452134.1XP_024307902.1  ribosomal RNA processing protein 1 homolog A isoform X3

    Conserved Domains (1) summary
    pfam05997
    Location:169
    Nop52; Nucleolar protein,Nop52
  3. XM_017028485.2XP_016883974.1  ribosomal RNA processing protein 1 homolog A isoform X1

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