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GIP2 Gip2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856781, updated on 7-Jun-2026
Official Symbol
GIP2
Official Full Name
Gip2p
Primary source
SGD:S000000856
Locus tag
YER054C
See related
AllianceGenome:SGD:S000000856; FungiDB:YER054C; VEuPathDB:YER054C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein phosphatase regulator activity. Involved in glycogen metabolic process. Part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to several human genes including PPP1R3B (protein phosphatase 1 regulatory subunit 3B) and PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See GIP2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (262052..263698, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Cu/Pi carrier Neighboring gene uncharacterized protein Neighboring gene ATP phosphoribosyltransferase Neighboring gene purine-cytosine permease

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Yeger-Lotem E, et al. Nat Genet, 2009 Mar. PMID 19234470, Free PMC Article
  2. Improvement in D-xylose utilization and isobutanol production in S. cerevisiae by adaptive laboratory evolution and rational engineering. Promdonkoy P, et al. J Ind Microbiol Biotechnol, 2020 Jul. PMID 32430798
  3. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Cheng C, et al. Yeast, 1997 Jan. PMID 9046081
  4. Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Williams-Hart T, et al. Genetics, 2002 Apr. PMID 11973298, Free PMC Article
  5. Epistatic buffering of fitness loss in yeast double deletion strains. Jasnos L, et al. Nat Genet, 2007 Apr. PMID 17322879

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
Gip2p
NP_010974.1
  • Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    262052..263698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178945.1 → NP_010974.1  Gip2p

    See identical proteins and their annotated locations for NP_010974.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLV7, P40036
    UniProtKB/TrEMBL
    N1PA40
    Conserved Domains (1) summary
    pfam03370
    Location:429 → 534
    CBM_21; Carbohydrate/starch-binding module (family 21)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40036.1

Gene LinkOut

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