MXR1 peptide-methionine-S-sulfoxide reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MXR1
Official Full Name: peptide-methionine-S-sulfoxide reductase
Primary source: SGD:S000000844
Locus tag: YER042W
See related: AllianceGenome:SGD:S000000844; FungiDB:YER042W; VEuPathDB:YER042W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables peptide-methionine (S)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MXR1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (234937..235491)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the plasticity of the Trx binding site on Mxr1 provides structural insights into the recognition of diverse substrates by a universal catalytic motif of Trx.
Title: Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1.
Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
Title: Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
MSRA and MSRB helps to preserve the function of cellular FeS clusters from oxidative inactivation.
Title: Methionine sulphoxide reductases protect iron-sulphur clusters from oxidative inactivation in yeast.
interacts with glutathione peroxidase Gpx3; Gpx3 functions as a redox-dependent exquisite regulator of the protein repair activity of Mxr1
Title: Glutathione peroxidase 3 of Saccharomyces cerevisiae regulates the activity of methionine sulfoxide reductase in a redox state-dependent way.
under normal growth conditions thioredoxin 1 is essential for msrA transcription and activity
Title: The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-methionine-(S)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (S)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-methionine (S)-S-oxide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-methionine (S)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (S)-S-oxide reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: peptide-methionine-S-sulfoxide reductase

NP_010960.1

EC 1.8.4.11

Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

234937..235491

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178933.1 → NP_010960.1 TPA: peptide-methionine-S-sulfoxide reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010960.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLU2, P40029

UniProtKB/TrEMBL

A6ZQZ1, B3LS55, C7GSI9, C8Z745, G2WCS5, N1PA37

Conserved Domains (1) summary

TIGR00401
Location:17 → 171

msrA; methionine-S-sulfoxide reductase