MXR1 peptide-methionine-S-sulfoxide reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MXR1
Official Full Name: peptide-methionine-S-sulfoxide reductase
Primary source: SGD:S000000844
Locus tag: YER042W
See related: AllianceGenome:SGD:S000000844; FungiDB:YER042W; VEuPathDB:YER042W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables peptide-methionine (S)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

the plasticity of the Trx binding site on Mxr1 provides structural insights into the recognition of diverse substrates by a universal catalytic motif of Trx.
Title: Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1.
Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
Title: Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
MSRA and MSRB helps to preserve the function of cellular FeS clusters from oxidative inactivation.
Title: Methionine sulphoxide reductases protect iron-sulphur clusters from oxidative inactivation in yeast.
interacts with glutathione peroxidase Gpx3; Gpx3 functions as a redox-dependent exquisite regulator of the protein repair activity of Mxr1
Title: Glutathione peroxidase 3 of Saccharomyces cerevisiae regulates the activity of methionine sulfoxide reductase in a redox state-dependent way.
under normal growth conditions thioredoxin 1 is essential for msrA transcription and activity
Title: The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-methionine (S)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-methionine (S)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (S)-S-oxide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-methionine (S)-S-oxide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-methionine (S)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
enables peptide-methionine (S)-S-oxide reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_010960.1

Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease